Effects of brinzolamide ophthalmic: A Synthesis of Findings from 7 Studies

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Original Abstract of the Article

Main Research Findings

Brinzolamide is an ophthalmic suspension used for the treatment of glaucoma and ocular hypertension. It is a carbonic anhydrase inhibitor that lowers intraocular pressure (IOP) by reducing the production of aqueous humor in the eye. 7 Research has shown that brinzolamide can lower IOP by up to 18%. 3 Brinzolamide has been shown to improve retinal and optic nerve blood flow in some studies. 2 However, the tissue distribution of brinzolamide compared to dorzolamide (another carbonic anhydrase inhibitor) shows that dorzolamide has significantly higher penetration in the aqueous humor, sclera, retina, vitreous humor, and optic nerve. 2 Brinzolamide, when combined with travoprost, has been found to be more effective in lowering IOP compared to travoprost alone. 5 In a study comparing brinzolamide to timolol, brinzolamide was found to be more effective at lowering IOP. 6 A study on the manufacturing process of brinzolamide ophthalmic suspension identified planetary centrifugal media milling as the most viable lab-scale technique due to its ability to produce the narrowest particle size distribution. 1 This study also investigated factors affecting the rheology of the suspension, such as the concentration of carbomer, shear rate, shear time, NaCl concentration, and mannitol concentration. 1

Benefits and Risks

Benefit Summary

Brinzolamide is effective in lowering intraocular pressure and has the potential to improve blood flow in the eye. 3 It can be used alone or in combination with other eye drops. 5 Brinzolamide has been shown to effectively lower IOP in several studies. 7 6 By lowering IOP, it helps prevent vision loss caused by glaucoma or ocular hypertension.

Risk Summary

Common side effects of brinzolamide include blurred vision, eye discomfort, and eye pain. 3 Non-ocular side effects such as taste perversion have also been reported. 4 It's important to be aware of these potential side effects when using brinzolamide.

Comparison of Studies

Similarities

Several studies have demonstrated the effectiveness of brinzolamide in lowering intraocular pressure. 7 6 5 4 3 2 This effect contributes to preventing vision loss caused by glaucoma and ocular hypertension. Brinzolamide can also be used in combination with other eye drops. 5

Differences

The effectiveness of brinzolamide in lowering IOP varies across different studies. 7 6 5 Similarly, the side effects associated with brinzolamide also vary between studies. 3 It is likely that the effectiveness and side effects of brinzolamide can differ based on individual patient factors and other medications they are using.

Consistency and Inconsistencies of Results

Numerous studies have shown that brinzolamide effectively reduces intraocular pressure. 7 6 5 4 3 2 However, there is variability in the reported effectiveness of IOP reduction across different studies. 7 6 5 Similarly, the reported side effects of brinzolamide vary between research findings. 3 It's important to acknowledge that individual patient characteristics and other medications they use can influence the effectiveness and side effects of brinzolamide.

Practical Implications

Brinzolamide has been demonstrated to lower intraocular pressure in numerous studies. 7 6 5 4 3 2 If you're prescribed brinzolamide, follow your doctor's instructions and ensure you have regular IOP check-ups.

Limitations of Current Research

More research is needed to fully understand the long-term safety and effectiveness of brinzolamide. Additionally, the effectiveness of brinzolamide in lowering IOP can vary from person to person.

Future Research Directions

Further research is necessary to better understand the long-term safety and effectiveness of brinzolamide. Studies are also needed to investigate individual patient responses to brinzolamide, allowing for personalized treatment plans.

Conclusion

Brinzolamide is an eye drop used to treat glaucoma and ocular hypertension. It lowers intraocular pressure and may improve blood flow in the eye. 3 It can be used alone or combined with other eye drops. 5 Brinzolamide has been shown to effectively lower IOP in several studies. 7 6 If you're prescribed brinzolamide, it's crucial to adhere to your doctor's instructions and have regular IOP check-ups.

Literature analysis of 7 papers
Positive Content
7
Neutral Content
0
Negative Content
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Article Type
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7
2.

Ocular pharmacokinetics of dorzolamide and brinzolamide after single and multiple topical dosing: implications for effects on ocular blood flow.

Author: KadamRajendra S, JadhavGajanan, OgidigbenMiller, KompellaUday B

Improve optic nerve blood flow
Improve retinal blood flow

This study compared the ocular pharmacokinetics and tissue distribution profiles of dorzolamide and brinzolamide after single and multiple topical applications. Dorzolamide showed significantly higher delivery to the aqueous humor, anterior sclera, posterior sclera, anterior retina, posterior retina, anterior vitreous, and optic nerve than brinzolamide.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

5.

Ocular hypotensive efficacy and safety of brinzolamide ophthalmic suspension 1% added to travoprost ophthalmic solution 0.004% therapy in patients with open-angle glaucoma or ocular hypertension.

Author: FranksWendy,

IOP reduction

Combined travoprost and brinzolamide therapy is more effective in lowering intraocular pressure compared to travoprost monotherapy for patients with open angle glaucoma or ocular hypertension.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

6.

Ocular hypotensive effect and safety of brinzolamide ophthalmic solution in open angle glaucoma patients.

Author: WangTsing-Hong, HuangJehn-Yu, HungPor T, ShiehJui-Wen, ChenYuh Fang

Intraocular pressure control

Brinzolamide, a topical carbonic anhydrase inhibitor, was compared to timolol for its effectiveness in reducing intraocular pressure.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

7.

Dose-response evaluation of the ocular hypotensive effect of brinzolamide ophthalmic suspension (Azopt). Brinzolamide Dose-Response Study Group.

Author: SilverL H

Reduce IOP
Abnormal taste
Blurred vision
Ocular discomfort

Brinzolamide is a medication used to lower intraocular pressure. This study found that the optimal concentration of brinzolamide is 1%.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

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