Effects of bromfenac ophthalmic: A Synthesis of Findings from 16 Studies

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Original Abstract of the Article

Major Research Findings

Bromfenac ophthalmic solution has been shown to be effective in treating anterior chamber inflammation after cataract surgery in multiple studies. 2 found that bromfenac 0.09% was more effective than dexamethasone 0.1% in reducing anterior chamber inflammation. 16 , 10 , 9 , 7 reported that bromfenac effectively reduces eye pain and inflammation after cataract extraction. 4 found that bromfenac can reduce discomfort after femtosecond laser-assisted LASIK surgery. 14 showed that bromfenac was well distributed in ocular tissues after topical instillation in rabbits. 1 reviewed 23 clinical studies that examined bromfenac use for conditions beyond cataract surgery and concluded that bromfenac is a safe and effective treatment for a wide range of ophthalmic conditions.

While bromfenac is effective in reducing anterior chamber inflammation, 8 reported a case of acute corneal melt associated with bromfenac use, suggesting the potential for serious adverse effects.

Benefits and Risks

Benefit Summary

Bromfenac ophthalmic solution can help reduce anterior chamber inflammation and eye pain after cataract surgery. 2 , 16 , 10 , 9 , 7 It can also reduce discomfort after femtosecond laser-assisted LASIK surgery. 4 It may also be effective in treating other inflammatory eye conditions beyond cataract surgery. 1

Risk Summary

Bromfenac ophthalmic solution can cause serious adverse effects, such as corneal melt. 8

Study Comparisons

Study Similarities

Many studies have consistently reported the efficacy of bromfenac ophthalmic solution in treating anterior chamber inflammation after cataract surgery. 2 , 16 , 10 , 9 , 7

Study Differences

The administration method, dosage, and duration of bromfenac ophthalmic solution use varied across studies. The type of surgery performed and the age of participants also differed.

Consistency and Contradictions of Findings

Multiple studies have consistently shown the effectiveness of bromfenac ophthalmic solution in treating anterior chamber inflammation after cataract surgery. 2 , 16 , 10 , 9 , 7 However, 8 highlights a potential for serious adverse events, such as corneal melt. While the occurrence of such adverse effects is rare and may not necessarily be attributed to bromfenac, caution is advised when using it.

Considerations for Real-World Application

Bromfenac ophthalmic solution shows potential for treating anterior chamber inflammation after cataract surgery; however, the risk of side effects should be taken into account. 8 It is essential to use it as directed by a doctor and seek immediate medical attention for any eye abnormalities.

Limitations of Current Research

Long-term safety data for bromfenac ophthalmic solution is limited. Not all studies have extensively investigated the incidence and severity of adverse events. Additionally, studies comparing the effectiveness and safety of bromfenac with other treatment options are still insufficient.

Future Research Directions

More research is needed to investigate the long-term safety, incidence and severity of adverse events, and comparisons with other treatment options for bromfenac ophthalmic solution. Further exploration of its potential efficacy in treating various inflammatory eye conditions is also warranted. 1

Conclusion

Bromfenac ophthalmic solution has shown promise in treating anterior chamber inflammation after cataract surgery. 2 , 16 , 10 , 9 , 7 However, reports of serious side effects, such as corneal melt, highlight the need for caution. 8 If considering bromfenac, it’s vital to follow a doctor’s instructions and be aware of potential risks.

Literature analysis of 16 papers
Positive Content
15
Neutral Content
0
Negative Content
1
Article Type
9
0
0
0
16
2.

Anterior Chamber Inflammation After Cataract Surgery: A Randomized Clinical Trial Comparing Bromfenac 0.09% to Dexamethasone 0.1.

Author: CoassinMarco, De MariaMichele, MastrofilippoValentina, BragliaLuca, CiminoLuca, SartoriAntonio, FontanaLuigi

Improved visual acuity
Reduced inflammation

A randomized study of 76 patients undergoing uncomplicated cataract surgery showed that short-term therapy with topical bromfenac alone was as effective as dexamethasone in reducing anterior chamber inflammation.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

3.

The Comparative Efficacy and Tolerability of Diclofenac 0.1% and Bromfenac 0.09% Ophthalmic Solutions after Cataract Surgery.

Author: GiannaccareGiuseppe, FinziAlessandro, SebastianiStefano, GrecoFedele, VersuraPiera, CamposEmilio C

Reduced inflammation
Reduced macular edema

Diclofenac and bromfenac ophthalmic solutions were compared as adjunctive therapy after cataract surgery. Diclofenac was more effective in reducing postoperative intraocular inflammation but bromfenac was more tolerable.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

5.

Comparison of topically applied flurbiprofen or bromfenac ophthalmic solution on post-operative ocular hypertension in canine patients following cataract surgery.

Author: LuJennifer, EnglishRobert, NadelsteinBrad, WeigtAnne, BerdoulayAndrew, BinderDan, NganEsther

Bromfenac higher risk
Elevated IOP

Bromfenac-treated eyes were more likely to require intervention for elevated IOP compared to flurbiprofen-treated eyes after cataract surgery.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

7.

Bromfenac ophthalmic solution 0.07% dosed once daily for cataract surgery: results of 2 randomized controlled trials.

Author: WaltersThomas R, GoldbergDamien F, PeaceJames H, GowJames A,

Effective for inflammation
Effective for pain
Safe

This study evaluated the efficacy and ocular safety of bromfenac ophthalmic solution 0.07% (Prolensa) for treating ocular inflammation and pain after cataract surgery. Bromfenac 0.07% dosed once daily was clinically safe and effective compared to placebo for treating ocular inflammation and pain. It may be a beneficial addition to the current standard of care.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

8.

Acute corneal melt associated with topical bromfenac use.

Author: PrasherPawan

Improved visual outcome
Corneal melt

Corneal melt can occur as a complication of excessive use of topical bromfenac in the presence of pre-existing ocular surface disorders.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

9.

Safety and efficacy of bromfenac ophthalmic solution (Bromday) dosed once daily for postoperative ocular inflammation and pain.

Author: HendersonBonnie A, GaytonJohnny L, ChandlerSimon P, GowJames A, KlierSharon M, McNamaraTimothy R,

Improved vision
Reduced inflammation
Reduced pain
Few adverse events

This pooled analysis of four randomized controlled trials evaluated the efficacy and ocular safety of bromfenac ophthalmic solution 0.09% for the treatment of ocular inflammation and pain following cataract surgery. Bromfenac 0.09% dosed once daily was found to be clinically safe and effective for reducing and treating ocular inflammation and pain.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

10.

Once daily dosing of bromfenac ophthalmic solution 0.09% for postoperative ocular inflammation and pain.

Author: SilversteinSteven M, CableMelissa G, SadriEhsan, PeaceJames H, FongRaymond, ChandlerSimon P, GowJames A, KlierSharon M, McNamaraTimothy R,

Reduced inflammation
Reduced pain
Few adverse events

This pooled analysis of two randomized controlled trials evaluated the efficacy and ocular safety of bromfenac ophthalmic solution 0.09% for the treatment of ocular inflammation and pain following cataract surgery. Bromfenac 0.09% dosed once daily was found to be clinically safe and effective for reducing and treating ocular inflammation and pain.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

11.

Efficacy and safety of bromfenac for the treatment of corneal ulcer pain.

Author: SchechterBarry A, TrattlerWilliam

Epithelial healing
Pain relief

A study of 25 eyes with corneal infiltrates treated with bromfenac ophthalmic solution 0.09% along with anti-infective agents found that bromfenac effectively treated pain associated with infectious keratitis. Bromfenac did not delay corneal epithelialization and was well-tolerated.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

12.

Efficacy of ophthalmic nonsteroidal antiinflammatory drugs in suppressing anterior capsule contraction and secondary posterior capsule opacification.

Author: MukaiKoichiro, MatsushimaHiroyuki, GotohNorihito, AoseMasamoto, SatoshiWatahiki, WataruTerauchi, MatsuiEichiro, NagataMayumi, SenooTadashi

Anterior capsule contraction prevention
PCO prevention

Postoperative treatment with ophthalmic nonsteroidal antiinflammatory drug solutions prevented anterior capsule contraction and posterior capsule opacification (PCO) in rabbit eyes.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

13.

Effect of bromfenac ophthalmic solution on ocular inflammation following cataract surgery.

Author: MiyanagaMasaru, MiyaiTakashi, NejimaRyohei, MaruyamaYoko, MiyataKazunori, KatoSatoshi

Improved visual acuity
Reduced inflammation
Macular edema

Bromfenac is as effective as betamethasone in minimizing inflammatory reactions after cataract surgery.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

14.

24-hour evaluation of the ocular distribution of (14)C-labeled bromfenac following topical instillation into the eyes of New Zealand White rabbits.

Author: BaklayanGeorge A, PattersonHal M, SongClara K, GowJames A, McNamaraTimothy R

Treats anterior and posterior inflammation

Significant penetration and measurable amounts of bromfenac were detected in all ocular tissues over 24 hours, suggesting its utility in treating inflammation of both the anterior and posterior ocular segments.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

15.

The systemic safety of bromfenac ophthalmic solution 0.09%.

Author: StewartRobert H, GrilloneLisa R, ShiffmanMitchell L, DonnenfeldEric D, GowJames A,

No systemic adverse effects

Bromfenac ophthalmic solution 0.09% is safe for the treatment of postoperative inflammation and reduction of ocular pain in subjects who have undergone cataract extraction.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

16.

Bromfenac ophthalmic solution 0.09% (Xibrom) for postoperative ocular pain and inflammation.

Author: DonnenfeldEric D, HollandEdward J, StewartRobert H, GowJames A, GrilloneLisa R,

Ocular inflammation clearance
Ocular pain reduction
Burning
Eye irritation
Photophobia
Stinging

Bromfenac ophthalmic solution 0.09% was found to be effective and safe for treating postoperative inflammation and reducing ocular pain after cataract extraction. This pooled analysis of two phase III clinical trials involving 527 patients found that bromfenac significantly reduced ocular inflammation and pain compared to placebo, with minimal side effects.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

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