Effects of deoxycholic acid injection: A Synthesis of Findings from 21 Studies

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Original Abstract of the Article

Major Research Findings

Deoxycholic acid injection (ATX-101) is a novel injectable drug approved in the United States (Kybella) and Canada (Belkyra) for the reduction of submental fat, commonly known as a double chin. 3 , 2 , 16 This drug works by breaking down fat cells, resulting in a reduction in the appearance of a double chin. 16 , 15 Clinical trials have shown that ATX-101 is effective in reducing submental fat and improving the appearance of the chin and neck. 17 , 11 , 21 ATX-101 has also been shown to be safe for most patients. 17 , 18 , 11 However, common side effects include pain, swelling, and bruising at the injection site, which are typically mild to moderate and transient. 17 , 18 , 7 Rare but serious complications have also been reported. , , 1 , 4 Researchers have found that proper injection technique and careful dosage adjustments can potentially minimize these side effects. 3 , 5 , 8

Benefits and Risks

Benefit Summary

Deoxycholic acid injections are an effective treatment option for reducing the appearance of a double chin, and have been found to be safe for most patients. Additionally, it offers a less invasive approach with a shorter recovery time compared to surgical interventions. 2 , 16 , , 7

Risk Summary

Deoxycholic acid injections can cause side effects such as pain, swelling, and bruising at the injection site. 17 , 18 , 7 Rare but serious complications can occur. , , 1 , 4

Study Comparison

Study Commonalities

Multiple studies have shown that deoxycholic acid injections are effective in reducing the appearance of a double chin. 17 , 11 , 21 Many studies also report injection-site side effects such as pain, swelling, and bruising. 17 , 18 , 7

Study Differences

Different studies have observed varying levels of effectiveness and side effects from deoxycholic acid injections. 11 , 21 These variations may be attributed to differences in study methodology and participant characteristics. 11 , 21 , 9 , 20 Researchers have noted the need for further research to better understand the long-term effects and safety of deoxycholic acid injections. 3 , 5 , 8

Consistency and Inconsistencies of Results

While multiple studies demonstrate the effectiveness of deoxycholic acid injections in reducing the appearance of a double chin, there are differences in the extent of effectiveness and the frequency of side effects reported. 11 , 21 These discrepancies could be attributed to differences in study methodology and participant characteristics. 11 , 21 , 9 , 20 Furthermore, the long-term effects and safety of deoxycholic acid injections remain incompletely understood. 16 , 7

Practical Application Considerations

Deoxycholic acid injections are a promising treatment option for reducing the appearance of a double chin, but it is essential to understand the potential risks. 17 , 18 , 7 Prior to considering this treatment, consulting with a qualified medical professional to discuss your individual health status and potential risks is crucial. 3 , 5 , 8

Limitations of Current Research

Current research on deoxycholic acid injections lacks comprehensive information on long-term effects and safety. 16 , 7 Additionally, the sample sizes in some studies are limited, making it difficult to generalize the findings to the broader population. 11 , 21 , 9 , 20

Future Research Directions

Further research on the long-term effects and safety of deoxycholic acid injections is necessary. 16 , 7 Studies involving diverse populations, including individuals with different age groups and health conditions, are also recommended. 11 , 21 , 9 , 20

Conclusion

Deoxycholic acid injections hold promise as an effective treatment option for reducing the appearance of a double chin. 16 However, it is crucial to understand the potential risks associated with this treatment. 17 , 18 , 7 Consult with a qualified healthcare professional to discuss your individual health status and potential risks before considering this treatment. 3 , 5 , 8 Further research on the long-term effects and safety of deoxycholic acid injections is anticipated. 16 , 7

Literature analysis of 21 papers
Positive Content
21
Neutral Content
0
Negative Content
0
Article Type
2
0
0
6
21
1.

Inadvertent intra-arterial injection of deoxycholic acid: A case report and proposed protocol for treatment.

Author: LindgrenAleksandra L, WelshKathleen M

Submental fat reduction
Intra-arterial injection
Necrosis

This abstract discusses the management of inadvertent intra-arterial injection of deoxycholic acid, a drug used to reduce submental fat.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

2.

ATX-101 (deoxycholic acid injection) for reduction of submental fat.

Author: AscherBenjamin, FellmannJere, MonheitGary

Submental fat reduction

ATX-101 (deoxycholic acid injection) is the only injectable drug approved in the United States and Canada for reduction of submental fat. This drug can reduce the appearance of a double chin with minimal side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

3.

Proper Technique for Administration of ATX-101 (Deoxycholic Acid Injection): Insights From an Injection Practicum and Roundtable Discussion.

Author: JonesDerek H, KenkelJeffrey M, FagienSteven, GlaserDee Anna, MonheitGary D, StaufferKaren, SykesJonathan M

Fat reduction
None mentioned

ATX-101, an injectable drug, is used to reduce submental fat. This article reports the findings of an injection practicum and roundtable discussion about the proper injection technique and anatomical placement of ATX-101.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

6.

ATX-101 (Deoxycholic Acid Injection) Treatment in Men: Insights From Our Clinical Experience.

Author: ShridharaniSachin M, BehrKathleen L

Submental fat reduction

ATX-101 (deoxycholic acid injection) is a new drug that is used to reduce excess submental fat, or a double chin. This study discusses the use of ATX-101 for this condition.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

7.

ATX-101 (Deoxycholic Acid Injection) for Reduction of Submental Fat: Results From a 12-Month Open-Label Study

Author: BeerKenneth, WeinkleSusan H., CoxSue Ellen, RubinMark G., ShambanAva, SomogyifChristine

SMF reduction
Treatment area pain

ATX-101 (deoxycholic acid) is a safe and effective treatment for submental fat (SMF) reduction. The safety and efficacy of ATX-101 were sustained over 12 months.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

8.

Deoxycholic Acid (ATX-101) for Fat Reduction.

Author: GuptaJyoti, KassirMartin, KroumpouzosGeorge, KatsambasAndreas, GaladariHassan, LottiTorello, WollinaUwe, GrabbeStephan, GoldustMohamad

Submental fat reduction

ATX-101 (deoxycholic acid injection) is a drug approved in the United States and Canada for reduction of moderate or severe submental fat in adults. It has been proven to be effective in submental fat reduction with a good safety profile.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

9.

ATX-101 (Deoxycholic Acid Injection) Leads to Clinically Meaningful Improvement in Submental Fat: Final Data From CONTOUR.

Author: BehrKathleen, KavaliCarmen M, MunavalliGirish, TellerCraig F, YoelinSteve, BreshearsLaura, SanghaSara

Effective SMF reduction

ATX-101 (deoxycholic acid injection) was effective in reducing submental fat (SMF) in patients who met their treatment goals. Successful outcomes were associated with careful patient selection, adequate volume administration, and an appropriate number of treatments.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.

Language : English

10.

A phase 1 pharmacokinetic study of ATX-101: serum lipids and adipokines following synthetic deoxycholic acid injections.

Author: WalkerPatricia, LeeDaniel

Contouring the submental area

ATX-101, a formulation of deoxycholic acid, is being investigated as an injectable treatment for reducing submental fat (SMF). The drug works by causing targeted destruction of fat cells in the area of injection.

Clinical Trial, Phase IThe first stage of clinical trials in humans. Evaluates the safety, tolerability, and pharmacokinetics of a new drug/treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

11.

Efficacy and Safety of ATX-101 by Treatment Session: Pooled Analysis of Data From the Phase 3 REFINE Trials.

Author: DayanSteven H, SchlessingerJoel, BeerKenneth, DonofrioLisa M, JonesDerek H, HumphreyShannon, CarruthersJean, LizzulPaul F, GrossTodd M, BeddingfieldFrederick C, SomogyiChristine

Increased satisfaction
SMF reduction

ATX-101 (deoxycholic acid injection) was shown to be effective in reducing submental fat (SMF) and the psychological impact of SMF. In a phase 3 study, patients who received ATX-101 were significantly more satisfied with the appearance of their face/chin at 12 weeks after last treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

12.

Future Applications of Deoxycholic Acid in Body Contouring.

Author: SykesJonathan M, AllakAmir, KlinkBrian

Contour change
Fat reduction
Less invasive

Deoxycholic acid (KybellaTM) is an FDA-approved injectable treatment for reducing submental fat, providing a less invasive alternative to surgical liposuction. The authors propose that KybellaTM could potentially be used to reduce excessive subcutaneous fat in other regions of the body, although this would be off-label and require careful consideration of regional anatomy and potential complications.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

13.

Injection of an Adipocytolytic Agent for Reduction of Excess Periaxillary Fat.

Author: ShridharaniSachin M

Reduced APAF
Injection site reactions

This retrospective study evaluated the efficacy and safety of ATX-101 (deoxycholic acid injection) for reducing excess anterior periaxillary fat (APAF). ATX-101 effectively reduced APAF in 10 out of 12 patients and was generally well tolerated. Common adverse events included injection-site numbness, edema, and tenderness.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

14.

Improvement in Jowl Fat following ATX-101 Treatment: Results from a Single-Site Study.

Author: ShridharaniSachin M

Jowl fat reduction

ATX-101 (deoxycholic acid injection) is a minimally invasive treatment that has been approved for submental fat reduction. This study evaluated the efficacy and safety of ATX-101 for reducing jowl fat.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Video-Audio MediaMedia that combines video and audio. Includes movies, TV shows, and online videos.

Language : English

15.

Histological Analysis of the Effect of ATX-101 (Deoxycholic Acid Injection) on Subcutaneous Fat: Results From a Phase 1 Open-Label Study.

Author: WalkerPatricia S, LeeDaniel R, TothBryant A, BowenBeta

Reduced subcutaneous fat
Inflammation
Septal thickening

This Phase 1 open-label study characterized the histological effect of ATX-101 injection into subcutaneous fat. ATX-101 induced adipocytolysis, local inflammation, septal thickening, and resolution of inflammation by 28 days after injection.

Clinical Trial, Phase IThe first stage of clinical trials in humans. Evaluates the safety, tolerability, and pharmacokinetics of a new drug/treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

16.

Overview of ATX-101 (Deoxycholic Acid Injection): A Nonsurgical Approach for Reduction of Submental Fat.

Author: DayanSteven H, HumphreyShannon, JonesDerek H, LizzulPaul F, GrossTodd M, StaufferKaren, BeddingfieldFrederick C

Fat reduction
None mentioned

ATX-101 is the first injectable drug approved for submental fat reduction. This article reviews the clinical development program and long-term follow-up studies that demonstrate the efficacy and safety of ATX-101, confirming its long-lasting effect and minimally invasive nature.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

17.

Management of Patient Experience With ATX-101 (Deoxycholic Acid Injection) for Reduction of Submental Fat.

Author: DoverJeffrey S, KenkelJeffrey M, CarruthersAlastair, LizzulPaul F, GrossTodd M, SubramanianMeenakshi, BeddingfieldFrederick C

Fat reduction
Injection site reactions

ATX-101, a drug for submental fat reduction, is associated with common injection-site reactions. This article presents management considerations for these adverse events, including pre-treatment options, post-treatment interventions, and medication recommendations to reduce the risk of bruising.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

18.

Prevention and Management of Injection-Related Adverse Effects in Facial Aesthetics: Considerations for ATX-101 (Deoxycholic Acid Injection) Treatment.

Author: FagienSteven, McChesneyPatricia, SubramanianMeenakshi, JonesDerek H

Fat reduction
Bruising
Pain
Swelling

ATX-101, a drug approved for submental fat reduction, is associated with injection-site reactions. This article provides practical management considerations for these adverse events, including pre-treatment options, post-treatment interventions, and medication recommendations to minimize bruising.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

19.

Safety and Efficacy of Deoxycholic Acid for Reduction of Upper Inner Thigh Fat.

Author: YuanJoyce, ShafiqFaiza, OrtizArisa

Fat reduction
Improved thigh gap
Side effects

Deoxycholic acid injection was found to be safe and effective for reducing upper inner thigh fat in a Phase I study of 15 subjects. Significant reductions in thigh circumference and upper inner thigh skin fold thickness were observed at 12 weeks after treatment, with 86% of patients reporting satisfaction with the treatment.

Clinical Trial, Phase IThe first stage of clinical trials in humans. Evaluates the safety, tolerability, and pharmacokinetics of a new drug/treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

20.

Final Data from the Condition of Submental Fullness and Treatment Outcomes Registry (CONTOUR)

Author: PalmMelanie D., SchlessingerJoel, CallenderValerie D., FagienSteven, BeerKenneth, MaganteSuzanne, SanghaSara

SMF treatment

Submental fullness, a common aesthetic concern, can be treated with surgical procedures, energy-based devices, or injectable treatments. The CONTOUR registry, a prospective observational study of 1029 patients, investigated the outcomes of various treatments for submental fat (SMF). The study found that cost was the primary driver for patient decisions, treatment choice was influenced by SMF severity and preference for invasive or noninvasive procedures, and noninvasive/minimally invasive treatments were attractive options for patients new to facial aesthetic treatments.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Observational StudyResearch that observes and collects data on participants' behavior and outcomes in their natural state, without intervention.

Language : English

21.

A Double-Blind, Placebo-Controlled, Phase 3b Study of ATX-101 for Reduction of Mild or Extreme Submental Fat.

Author: GlogauRichard G, GlaserDee Anna, CallenderValerie D, YoelinSteve, DoverJeffrey S, GreenJeremy B, BreshearsLaura, BowenBeta

Improved skin laxity
Increased satisfaction
Reduced psychological impact
Reduced submental fat
Injection site reactions
Mild/moderate adverse events

ATX-101 (deoxycholic acid injection) is efficacious and well-tolerated for reduction of mild or extreme submental fat (SMF). A composite CR-1/PR-1 response (≥1-grade improvement in SMF from baseline) was achieved by 61.3% of ATX-101-treated subjects with mild SMF versus 6.7% of placebo-treated subjects and 89.3% of ATX-101-treated subjects with extreme SMF versus 13.3% of placebo-treated subjects.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

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