Effects of ergotamine and caffeine: A Synthesis of Findings from 13 Studies

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Original Abstract of the Article

Main Research Findings

Ergotamine and caffeine have been widely used in the treatment of migraine, and numerous studies have investigated their efficacy and risks. 10 suggests that ergotamine and caffeine may cause delirium, hallucinations, and mental status changes in elderly patients with chronic migraine. Meanwhile, 4 reports its effectiveness in treating headaches after lumbar puncture. Additionally, 3 suggests its effectiveness in elevating blood pressure and improving presyncope symptoms in patients with autonomic failure. These findings indicate that ergotamine and caffeine can be effective in treating migraine, but they also have the potential to cause side effects.

Benefits and Risks

Benefit Summary

Ergotamine and caffeine may be effective in treating migraine. suggests its effectiveness in treating headaches after lumbar puncture and pneumoencephalography. Additionally, 4 reports its effectiveness in treating headaches after lumbar puncture. Furthermore, 3 shows that ergotamine and caffeine can be effective in raising blood pressure and improving symptoms of presyncope in patients with autonomic failure.

Risk Summary

Ergotamine and caffeine may cause serious side effects, including hallucinations, mental status changes, and even birth defects. 10 suggests that ergotamine and caffeine may cause delirium, hallucinations, and mental status changes in elderly patients with chronic migraine. 13 suggests that ergotamine and caffeine may be associated with birth defects in infants exposed during pregnancy. Furthermore, 7 indicates that overuse of ergotamine and caffeine can lead to chronic headaches.

Comparison of Studies

Similarities in Studies

The studies included here indicate that ergotamine and caffeine can be effective in treating migraine, but they also have the potential to cause side effects. The common finding across these studies is that ergotamine and caffeine can be effective in treating migraine, but they also pose potential risks of side effects.

Differences in Studies

These studies have shown varied results in terms of the efficacy and risks of ergotamine and caffeine. For instance, 10 suggests that ergotamine and caffeine can cause hallucinations and mental status changes, which is not mentioned in other studies. Additionally, 3 states that ergotamine and caffeine can be effective in increasing blood pressure in patients with autonomic failure, which is not reported in other studies. These discrepancies could be due to differences in study populations, methodologies, or types and dosages of ergotamine and caffeine used.

Consistency and Contradictions in Results

These study findings exhibit both consistency and contradictions. For example, 10 and 7 suggest that ergotamine and caffeine can potentially cause mental status changes and chronic headaches. On the other hand, 4 and 3 suggest that ergotamine and caffeine may be effective in treating migraine and autonomic failure. These discrepancies might stem from variations in study populations, methodologies, and even the types and dosages of ergotamine and caffeine used.

Real-Life Application Notes

Ergotamine and caffeine can be effective in treating migraine, but they can also cause serious side effects. Therefore, it is crucial to follow your doctor's instructions when using ergotamine and caffeine and avoid self-medication. Especially if you are pregnant or breastfeeding, or have underlying conditions like heart disease or liver disease, avoid ergotamine and caffeine and consult your doctor.

Limitations of Current Research

These studies have not fully elucidated the efficacy and risks of ergotamine and caffeine. More research is needed to gain a comprehensive understanding of these aspects.

Future Research Directions

Further research is necessary to delve deeper into the efficacy and risks of ergotamine and caffeine. Particularly, more data is required regarding the types and dosages of ergotamine and caffeine, the incidence rate of side effects, and the duration of their effectiveness.

Conclusion

Ergotamine and caffeine have the potential to be effective in treating migraine, but they also carry the risk of serious side effects. These research findings highlight the importance of following your doctor's instructions when using ergotamine and caffeine and avoiding self-medication. Moreover, additional research is imperative to comprehensively understand the efficacy and risks associated with ergotamine and caffeine.

Literature analysis of 13 papers
Positive Content
9
Neutral Content
0
Negative Content
4
Article Type
2
0
0
2
13
4.

The analgesic and antiemetic efficacy of gabapentin or ergotamine/caffeine for the treatment of postdural puncture headache.

Author: ErolD D

Antiemetic effect
PDPH pain relief

Gabapentin significantly reduced pain, nausea, and vomiting compared to Cafergot in patients with postdural puncture headache (PDPH). Gabapentin and Cafergot were well tolerated with no adverse events.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

5.

Spotlight on eletriptan in migraine.

Author: McCormackPaul L, KeatingGillian M

Improved quality of life
Migraine treatment
Rapid onset of action

Eletriptan is a medication that can be used to treat migraines. This study found that eletriptan was effective in treating moderate to severe migraines and was superior to placebo as early as 30 minutes after administration. Eletriptan was also well tolerated and improved patients' quality of life.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

6.

Eletriptan: a review of its use in the acute treatment of migraine.

Author: McCormackPaul L, KeatingGillian M

Improved quality of life
Migraine treatment
Rapid onset of action

Eletriptan is an effective treatment for migraine attacks in adults. It is a triptan that works by activating serotonin receptors, and it is well tolerated. It is a good first-line treatment option.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

7.

Orbitofrontal cortex involvement in chronic analgesic-overuse headache evolving from episodic migraine.

Author: FumalArnaud, LaureysSteven, Di ClementeLaura, BolyMélanie, BohotinValentin, VandenheedeMichel, CoppolaGianluca, SalmonEric, KupersRon, SchoenenJean

Analgesic overuse
Chronic daily headache

This study measured glucose metabolism with 18-FDG PET in 16 chronic migraineurs with analgesic overuse before and 3 weeks after medication withdrawal. Medication overuse headache was associated with reversible metabolic changes in pain processing structures, but also with persistent orbitofrontal hypofunction, which could predispose subgroups of migraineurs to recurrent analgesic overuse.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

8.

Transformed migraine is a cause of chronic daily headaches.

Author: KonnoS, MeyerJ S, MargishviliG M, RauchR A, HaqueA

Avoid analgesic abuse

Acetazolamide can provoke migraine headaches in people with chronic daily headaches, which suggests that these headaches may be a form of transformed migraine.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Language : English

9.

Crossover comparison of efficacy and preference for rizatriptan 10 mg versus ergotamine/caffeine in migraine.

Author: ChristieSuzanne, GöbelHartmut, MateosValentin, AllenChristopher, VrijensFrance, ShivaprakashMalathi,

Faster Headache Relief
Improved Function
Migraine Treatment
Dizziness
Nausea
Somnolence

Rizatriptan is a drug used to treat migraine headaches. It is preferred over ergotamine/caffeine by patients because it works faster and has fewer side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

10.

Possible ergotamine-caffeine-associated delirium.

Author: GulbransonScott H, MockRoy E, WolfreyJeffrey D

Hallucination
Mental status change

This case report presents a possible association between ergotamine-caffeine consumption and severe mental status changes and hallucinations in an elderly patient with chronic migraines.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

11.

Pheochromocytoma crisis caused by contemporary ergotamine, caffeine, and nimesulide administration.

Author: Del RossoA, FradellaG, RussoL, BartoliP, BonechiF, BrandinelliA, MaioliM, MazzaF, SansoniM, ZipoliA, MannelliM, IeriA

Multiple organ failure

This study describes a case of a patient with pheochromocytoma who experienced multiple organ failure after taking ergotamine, caffeine, and nimesulide. The patient recovered completely after surgical intervention.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

13.

Birth defects following maternal exposure to ergotamine, beta blockers, and caffeine.

Author: HughesH E, GoldsteinD A

Arrested cerebral maturation
Birth defects
Paraplegia

Exposure to ergotamine, caffeine, and propranolol during pregnancy may be associated with vascular disruptive birth defects, such as arrested cerebral maturation and paraplegia.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

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