Effects of temazepam: A Synthesis of Findings from 7 Studies

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Original Abstract of the Article

Major findings

Temazepam is a benzodiazepine medication used to treat sleep disorders. Several studies have shown that temazepam can improve sleep quality and make it easier to fall asleep. However, it is important to be aware that temazepam may also have potential side effects. These studies used various methods to investigate the effects of temazepam. 5 evaluated the effects of temazepam on cognitive function in healthy volunteers using an adaptive tracking test, analysis of smooth-pursuit and saccadic eye movements, and visual analog scales. The results showed that temazepam affects cognitive function in a dose-dependent manner. In particular, 20 mg of temazepam had a significant effect on all tests, with peak effects observed 30 minutes after administration. 2 found that temazepam improved sleep in insomniac patients in a long-term sleep laboratory study. Temazepam was administered at 15 mg or 30 mg and remained effective for up to 5 weeks. However, suppression of slow-wave sleep was observed at the higher dose. Also, 1 showed that temazepam affects psychomotor skills and memory. 10 mg of temazepam impaired coordination skills, and 20 mg of temazepam impaired coordination, learning, and memory. These studies suggest that temazepam may improve sleep but also reveal that it may affect cognitive function and psychomotor skills. 3 suggested that temazepam may be effective in improving sleep in hospitalized patients. However, this study compared temazepam with amylobarbitone sodium and found no significant difference between the two. In addition, suggested that temazepam is effective for idiopathic and transient insomnia. This study showed that temazepam improved sleep quality without adversely affecting performance after sleep. Furthermore, 4 showed that temazepam promotes sleep onset and improves sleep quality. This study showed that temazepam is as effective as conventional benzodiazepines but also has less morning drowsiness. 7 showed that temazepam is less likely to affect the EEG, psychomotor performance, and subjective mental and emotional state than nitrazepam. This study suggested that temazepam may have a lower risk of side effects than nitrazepam.

Benefits and Risks

Benefits Summary

Temazepam may be effective in treating sleep disorders. Several studies have shown that temazepam improves sleep quality and makes it easier to fall asleep. Also, temazepam may have less morning drowsiness compared to other benzodiazepines. 4

Risks Summary

Temazepam may have a risk of side effects. These side effects include drowsiness, dizziness, decreased concentration, and memory impairment. Temazepam may also be addictive. 5

Comparison between studies

Commonalities

All these studies suggest that temazepam may improve sleep quality. All of these studies also show that temazepam may affect cognitive function and psychomotor skills.

Differences

These studies have shown different results regarding the effects of temazepam on cognitive function and psychomotor skills. For example, 5 showed that temazepam had a significant effect on the adaptive tracking test, eye movement analysis, and visual analog scales. On the other hand, 4 showed that temazepam did not affect morning drowsiness.

Consistency and discrepancies of results

These studies suggest that temazepam may improve sleep quality, but the effects of temazepam on cognitive function and psychomotor skills have yet to be fully elucidated. These studies used different methods and have shown different results. Therefore, further research is needed to investigate the effects of temazepam on cognitive function and psychomotor skills in more detail.

Things to note for practical application

Temazepam may be effective in treating sleep disorders, but it is also important to consider the risks of side effects. When using temazepam, it is essential to take the appropriate dosage as instructed by a doctor. Also, as temazepam may be addictive, it should be avoided for long periods, and use should be discussed with a doctor.

Limitations of current research

All of these studies were small-scale studies, and the number of participants was limited. Therefore, the results of these studies may not be generalizable. Also, these studies used different methods to investigate the effects of temazepam on cognitive function and psychomotor skills, making it difficult to compare the results.

Directions for future research

Large-scale studies are needed to investigate the effects of temazepam on cognitive function and psychomotor skills in more detail. It is also necessary to use different methods to compare and examine the effects of temazepam on cognitive function and psychomotor skills.

Conclusion

Temazepam may be effective in treating sleep disorders, but it is also important to consider the risks of side effects. When using temazepam, it is essential to take the appropriate dosage as instructed by a doctor. Further research is needed to investigate the effects of temazepam on cognitive function and psychomotor skills in more detail.

Literature analysis of 7 papers
Positive Content
6
Neutral Content
1
Negative Content
0
Article Type
7
0
0
0
7
1.

Acute effects of temazepam and nitrazepam on psychomotor skills and memory.

Author: LiljequistR, MattilaM J

Hypnotic effect
Impaired performance
Sedation

Temazepam and nitrazepam, both benzodiazepine hypnotics, were compared to placebo for their effects on psychomotor performance and cognitive function. Nitrazepam impaired reaction time, coordination, learning, and memory, while temazepam had more modest effects, mainly on coordination.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

Hypnotic efficacy of temazepam: a long-term sleep laboratory evaluation.

Author: MitlerM M, CarskadonM A, PhillipsR L, SterlingW R, ZarconeV P, SpiegelR, GuilleminaultC, DementW C

Insomnia treatment
No tolerance
Slow wave sleep suppression

Temazepam was safe and effective in treating insomnia at doses of 15 and 30 mg for up to 5 weeks. It suppressed slow wave sleep at the higher dose but did not suppress REM sleep.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

A clinical trial of temazepam, a sleep inducer, in hospital patients.

Author: PinesA, NandiA R, RahmanM, RaafatH, RooneyJ F

Sleep induction
Confusion
Drowsiness

Temazepam was found to be as effective as amylobarbitone sodium in inducing sleep, with fewer side effects, such as daytime dozing and morning hangover.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

4.

A 1,4-benzodiazepine, temazepam (K 3917), its effect on some psychological parameters of sleep and behaviour.

Author: HindmarchI

Improved sleep quality
Sleep induction
No early morning impairment

Temazepam, a benzodiazepine, was found to be effective in inducing sleep in healthy volunteers. It had a similar effect to conventional benzodiazepines but did not impair early morning behavior.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

5.

A comparison of the sensitivities of adaptive tracking, eye movement analysis and visual analog lines to the effects of incremental doses of temazepam in healthy volunteers.

Author: van SteveninckA L, SchoemakerH C, PietersM S, KroonR, BreimerD D, CohenA F

Impaired performance

Temazepam, in single oral doses of 5, 10, and 20 mg, caused effects on performance tests and subjective scores of alertness, with peak effects occurring at 30 minutes.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

6.

Psychopharmacological aspects of idiopathic and transient insomnia.

Author: HindmarchI

Improved insomnia
No performance impairment
Dose-dependent residual effects

Temazepam 20 mg was found to be effective in managing idiopathic insomnia and sleep difficulties, without any significant residual effects that could impair performance.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

7.

Pharmaco-EEG and Psychometric study of the effect of single doses of temazepam and nitrazepam.

Author: MatejcekM, NeffG, AbtK, WehrliW

Induces sleep
Reduces sleep latency
Hangover

Temazepam and nitrazepam, both benzodiazepine sedatives, were compared in a double-blind study. Temazepam had a faster onset of action, shorter duration of effect, and less impairment of psychomotor performance than nitrazepam, suggesting less hangover potential.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

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