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Long-term effects of continuous combined HRT on bone turnover and lipid metabolism in postmenopausal women.

Author: BarnesJ F, FarishE, FletcherC D, HartD M, HartH, NolanD, SpowartK

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This study followed 27 postmenopausal women for 10 years on continuous combined hormone replacement therapy (HRT). The results showed a significant and sustained increase in bone mineral density (BMD) in the lumbar spine, with a 5.5% increase compared to baseline after 10 years. While total cholesterol levels decreased significantly after 10 years, HDL cholesterol levels were reduced by 15.4%. Triglyceride and LDL cholesterol levels remained unchanged. This study suggests that continuous combined HRT may be a suitable option for long-term prevention of osteoporosis in postmenopausal women.
Paper Details　
Original Abstract of the Article :
This study was undertaken to investigate the effect of 10 years of hormone replacement therapy (HRT) on bone turnover and lipid metabolism in postmenopausal women. The single-centre trial was initiated as a 1-year, double-masked, randomized, parallel-group study of continuous combined HRT with 2 mg ...See full text at original site
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引用元：
https://doi.org/10.1007/s001980050071

データ提供：米国国立医学図書館（NLM）

Hormone Replacement Therapy: A Long-Term Study on Bone and Lipid Metabolism

Hormone replacement therapy (HRT) is a common treatment option for postmenopausal women, often used to manage symptoms like hot flashes and bone loss. This study investigates the long-term effects of HRT on bone turnover and lipid metabolism in postmenopausal women, providing valuable insights into its potential benefits and drawbacks. The researchers conducted a 10-year study, analyzing the impact of continuous combined HRT on bone mineral density (BMD) and lipid levels. The findings suggest that HRT can have a positive impact on bone health but may also affect certain lipid profiles. This research provides valuable information for women and their healthcare providers to make informed decisions about HRT.

HRT: A Positive Impact on Bone Health

The study shows that continuous combined HRT resulted in a significant and sustained increase in BMD over a 10-year period. This finding underscores the potential of HRT for the prevention and management of osteoporosis in postmenopausal women. The observed increase in BMD is an important piece of the puzzle, providing valuable evidence for the long-term benefits of HRT in this population. However, it's crucial to note that while HRT appears to be beneficial for bone health, it may also have an impact on lipid profiles.

Navigating the Desert of HRT

Like a camel traversing a vast desert, women considering HRT need to carefully weigh the potential benefits and risks. This study sheds light on the positive impact of HRT on bone health, but it also suggests that it may influence certain lipid profiles. It's important for women to have open and honest conversations with their healthcare providers to make informed decisions about HRT, taking into account their individual health needs and risk factors.

Dr.Camel's Conclusion

This research offers valuable information for women and their healthcare providers to navigate the desert of HRT. It underscores the importance of long-term studies to understand the full impact of treatments, especially when it comes to managing complex conditions like osteoporosis and cardiovascular health. A balanced approach, considering both the potential benefits and risks, is crucial for making informed decisions about HRT.

Date :
  1. Date Completed 1999-03-08
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

10024902

DOI: Digital Object Identifier

10.1007/s001980050071

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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