Effect of electrolyte and solvent composition on capillary electrophoretic separation of some pharmaceuticals in non-aqueous media.

Author: JyskeP, PorrasS P, RiekkolaM L, ValkóI E

Paper Details 
Original Abstract of the Article :
Non-aqueous capillary electrophoresis was used to study the separation selectivity of positively charged drug substances and negatively charged diuretics. Study was made of the effects of organic solvent composition and the background electrolyte on the separation. The separation selectivity could b...See full text at original site
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引用元:
https://doi.org/10.1016/s0165-022x(98)00031-1

データ提供:米国国立医学図書館(NLM)

The Magic of Non-Aqueous Capillary Electrophoresis

The field of analytical chemistry is always seeking new and innovative ways to separate and analyze complex mixtures. This research explores the potential of non-aqueous capillary electrophoresis (NACE) for the separation of pharmaceuticals. The authors delve into the intricate interplay between the electrolyte composition, solvent composition, and separation selectivity in NACE, demonstrating how subtle changes in these parameters can dramatically affect the separation process. It's like a desert alchemist carefully blending different ingredients to create a unique potion. The study provides a deeper understanding of the underlying principles governing NACE, offering a powerful tool for analyzing complex mixtures.

Tuning the Separation Process

The authors demonstrate that the separation selectivity in NACE can be precisely tuned by carefully adjusting the composition of the electrolyte and the solvent. This is like a desert nomad customizing their camel's saddle to suit the specific challenges of the journey. These findings provide valuable insights into the optimization of NACE for the analysis of pharmaceuticals, allowing for enhanced separation and improved identification of individual components.

Navigating the Desert of Analytical Chemistry

This research provides a valuable roadmap for navigating the complex desert of analytical chemistry. It highlights the importance of carefully controlling the parameters of NACE to achieve optimal separation of complex mixtures. The study's findings encourage a meticulous and thoughtful approach to analytical chemistry, akin to a desert explorer meticulously planning their route to maximize their chances of success.

Dr. Camel's Conclusion

This research underscores the potential of NACE as a powerful analytical tool, highlighting the importance of carefully controlling the separation parameters to achieve optimal results. The study provides valuable insights into the intricate world of analytical chemistry, encouraging a meticulous and informed approach to this fascinating field.

Date :
  1. Date Completed 1999-05-13
  2. Date Revised 2019-09-15
Further Info :

Pubmed ID

10075266

DOI: Digital Object Identifier

10.1016/s0165-022x(98)00031-1

Related Literature

SNS
PICO Info
in preparation
Languages

English

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