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Long-term effects of finasteride on prostate tissue composition.

Author: DoreyF J, EpsteinJ I, GarrisJ B, GormleyG J, MacairanM L, MarksL S, PartinA W, SantosP B, SheryE D, StonerE, deKernionJ B

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Long-term finasteride treatment (24 to 30 months) results in a marked involution of the prostate epithelium, which continues to progress for many months after clinical effects stabilize. In a study of 19 men with symptomatic benign prostatic hyperplasia (BPH), decreases in symptom score, dihydrotestosterone and prostate-specific antigen levels, and prostate volume occurred at 6 months and were maintained without further long-term decreases.
Paper Details　
Original Abstract of the Article :
OBJECTIVES: To determine the long-term effects of finasteride treatment on prostate tissue composition; to relate these effects to clinical outcomes; and to test the hypothesis that finasteride exerts a selective or preferential action on the transition zone. METHODS: Nineteen men with symptomatic ...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/10096387

データ提供：米国国立医学図書館（NLM）

Long-Term Effects of Finasteride on Prostate Tissue Composition

This study investigates the long-term impact of finasteride, a medication used to treat benign prostatic hyperplasia (BPH), on prostate tissue composition. The researchers aimed to understand the mechanism behind finasteride's effectiveness and to determine whether its effects are specific to the transition zone of the prostate.

Finasteride Induces Progressive Involution of Prostate Epithelium

The study found that long-term treatment with finasteride led to a significant and progressive involution of the prostate epithelium, both in the peripheral and transition zones. This effect was observed even after clinical symptoms stabilized, suggesting that the continued contraction of the epithelium may be the key mechanism behind finasteride's sustained benefits.

Implications for Prostate Health

These findings have important implications for understanding the long-term effects of finasteride treatment for BPH. While the study suggests that finasteride effectively reduces prostate volume and alleviates symptoms, it also highlights the potential for long-term changes in prostate tissue composition. Further research is needed to assess the implications of these changes for long-term prostate health.

Dr.Camel's Conclusion

This study provides valuable insights into the complex interplay between finasteride and prostate tissue. By demonstrating the progressive involution of prostate epithelium, the research sheds light on the underlying mechanisms responsible for finasteride's effectiveness in treating BPH. While the study underscores the potential benefits of finasteride, it also emphasizes the need for further research to fully understand the long-term consequences of these tissue changes for prostate health. This research serves as a reminder that even seemingly straightforward treatments can have multifaceted effects, underscoring the importance of continuous investigation and careful monitoring of long-term outcomes.

Date :
  1. Date Completed 1999-04-22
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

10096387

DOI: Digital Object Identifier

S0090-4295(98)00567-6

SNS
PICO Info
in preparation
Languages

English

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