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Severe hyponatraemia in an amiloride/hydrochlorothiazide-treated patient.

Author: MuddeA H, van AssenS

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Thiazide diuretics can cause water retention in susceptible patients. This was demonstrated by a 'thiazide provocation test' in a patient with severe hyponatraemia.
Paper Details　
Original Abstract of the Article :
A 85-year-old woman treated with, among other drugs, a thiazide diuretic presented with a severe hyponatraemia. She met several of the criteria for SIADH and, besides drugs, no cause for SIADH was found. After stopping the thiazide diuretic and restricting fluid intake the patient recovered fully. I...See full text at original site
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引用元：
https://doi.org/10.1016/s0300-2977(98)00153-3

データ提供：米国国立医学図書館（NLM）

Thiazide Diuretics: A Paradoxical Effect on Water Balance

Thiazide diuretics are commonly used to treat high blood pressure, but they can have paradoxical effects on water balance. This research reports a case of severe hyponatremia (low blood sodium) in a patient receiving amiloride/hydrochlorothiazide, a combination diuretic. The study investigates the potential role of thiazide diuretics in causing water intoxication.

A Thiazide Provocation Test: Unraveling the Paradox

The study demonstrates that thiazide diuretics can, in certain individuals, lead to water retention rather than water loss. The researchers successfully rechallenged the patient with a single dose of amiloride/hydrochlorothiazide, confirming the role of the thiazide component in causing the water intoxication.

Navigating Diuretic Therapy: Individualized Approaches

This research highlights the importance of individualized approaches to diuretic therapy. The study emphasizes that certain patients may be more susceptible to the paradoxical water retention effect of thiazide diuretics. Patients receiving thiazide diuretics should be monitored closely for signs of hyponatremia.

Dr. Camel's Conclusion

Water balance can be a delicate dance in the desert—too much or too little can be detrimental. This research provides a cautionary tale regarding the paradoxical effects of thiazide diuretics, emphasizing the importance of careful monitoring and individualized treatment approaches.

Date :
  1. Date Completed 1999-04-21
  2. Date Revised 2019-11-03
Further Info :

Pubmed ID

10189785

DOI: Digital Object Identifier

10.1016/s0300-2977(98)00153-3

Related Literature

Article Analysis
・Effects of amiloride and hydrochlorothiazide
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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