Cytoprotective effects of trimetazidine in carmustine cholestasis.

Author: DemirA, GirginF, KuralayF, OzutemizO, TanyalcinT, TüzünS

Paper Details 
Original Abstract of the Article :
Carmustine [1 ,3-bis(2-chloroethyl)-1-nitrosurea (BCNU)] is an antitumour agent, however, its usefulness has been limited by a side effect; which involves pericholangitis and intrahepatic cholestasis. The primary effects of cholestasis is well known; bile flow retention, intracellular Ca++ accumulat...See full text at original site
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引用元:
https://doi.org/10.1016/S0940-2993(99)80015-3

データ提供:米国国立医学図書館(NLM)

Assessing Embolic Burden in Pulmonary Embolism: A Guide for Prognosis

Greetings, fellow adventurers! Dr. Camel here, your guide through the sometimes-tricky terrain of pulmonary embolism (PE), a condition where blood clots travel to the lungs. This study explores the importance of assessing the extent of these clots, known as embolic burden, in determining the prognosis for patients with PE. The researchers conducted a meta-analysis, combining data from multiple studies, to investigate the relationship between embolic burden and patient outcomes.

Mapping the Embolic Terrain: A Guide for Prognosis

The study revealed that the location of the emboli within the lung arteries, as assessed by computed tomography angiography (CTA), was a significant predictor of 30-day mortality. However, the study found no direct correlation between the overall amount of lung tissue blocked by clots and patient outcomes. This suggests that the location of the clots, rather than just their overall amount, plays a crucial role in determining the severity of PE and the likelihood of complications.

Navigating the Desert of Pulmonary Embolism

Imagine the pulmonary arteries as a network of narrow pathways through a vast desert. This study highlights the importance of carefully mapping these pathways and identifying the location of potential blockages to effectively guide treatment and improve patient outcomes. By recognizing the specific areas affected by emboli, healthcare providers can better tailor treatment strategies and potentially prevent serious complications.

Dr. Camel's Conclusion

This study underscores the importance of accurately assessing embolic burden in patients with PE, particularly the location of the clots within the lung arteries. This information is crucial for determining prognosis, tailoring treatment, and potentially preventing serious complications. By understanding the complexities of PE and utilizing appropriate diagnostic tools, we can navigate the desert of this challenging condition and improve the well-being of our patients.

Date :
  1. Date Completed 1999-09-16
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

10445391

DOI: Digital Object Identifier

10.1016/S0940-2993(99)80015-3

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Article Analysis
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PICO Info
in preparation
Languages

English

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