The protein kinase C inhibitor CGP41251 suppresses cytokine release and extracellular signal-regulated kinase 2 expression in cancer patients.

Author: BalkwillF, BraybrookJ, CaponigroF, DobbsN, FabbroD, GanesanT, HarrisA, HutchisonC, ManA, McDonaldA, PropperD, TalbotD, ThavasuP, TwelvesC

Paper Details 
Original Abstract of the Article :
Components of cell signaling pathways provide important targets for anticancer drugs. Protein kinase C (PKC) is a serine/threonine-specific kinase that regulates cell growth and differentiation. It is also implicated in tumor promotion. The staurosporine analogue CGP41251 is a PKC inhibitor, and it ...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/10463595

データ提供:米国国立医学図書館(NLM)

CGP41251: A Protein Kinase C Inhibitor with Potential Anticancer Activity

This research explores the potential of CGP41251, a protein kinase C (PKC) inhibitor, as a novel anticancer agent. The study investigates the in vivo biological activity of CGP41251 in cancer patients, examining its effects on cytokine release and the expression of a key signaling molecule, extracellular signal-regulated kinase 2 (ERK2). The authors provide valuable insights into the potential mechanisms of action and efficacy of CGP41251 in cancer treatment.

Targeting Cell Signaling Pathways for Cancer Treatment

The study demonstrates that CGP41251 effectively inhibits PKC activity in cancer patients, leading to a significant reduction in cytokine release and ERK2 expression. This suggests that CGP41251 could potentially modulate key cell signaling pathways involved in cancer growth and progression, offering a promising therapeutic approach for cancer treatment.

Unlocking the Potential of PKC Inhibitors for Cancer Therapy

This research provides further evidence for the potential of PKC inhibitors as a valuable tool in the fight against cancer. The findings suggest that CGP41251 could potentially be a valuable addition to the existing arsenal of anticancer therapies, offering hope for new and effective treatments for patients battling this devastating disease.

Dr.Camel's Conclusion

This research is like a camel caravan venturing into a vast desert, searching for new pathways to combat cancer. The study highlights the potential of CGP41251, a protein kinase C inhibitor, as a promising weapon against cancer. By targeting key signaling pathways, this drug could help us to conquer this formidable disease and find a way out of the desert of cancer, leading to a healthier future for those affected by this devastating illness.

Date :
  1. Date Completed 1999-09-16
  2. Date Revised 2016-11-24
Further Info :

Pubmed ID

10463595

DOI: Digital Object Identifier

10463595

Related Literature

SNS
PICO Info
in preparation
Languages

English

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