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Antibacterial activity of the white precipitate formed on the corneal surface after treatment with ciprofloxacin ophthalmic solution.

Author: JosephP R, MadhavanH N, RaoS K, SulochanaK N

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

The white crystalline precipitate formed on the corneal surface after topical administration of 0.3% ciprofloxacin ophthalmic solution exhibited bacterial inhibitory activity, indicating that the precipitate may function as a drug depot.
Paper Details　
Original Abstract of the Article :
PURPOSE: To determine the antibacterial activity of the white crystalline precipitate formed on the corneal surface after topical administration of 0.3% ciprofloxacin ophthalmic solution by microbiologic assay. METHODS: White crystalline precipitate formed on the corneal surface of seven patients w...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/10487428

データ提供：米国国立医学図書館（NLM）

Ciprofloxacin Precipitate: A Unexpected Drug Depot?

This [clinical study] investigates the antibacterial activity of the white precipitate formed on the corneal surface after topical administration of ciprofloxacin ophthalmic solution. The authors found that the precipitate exhibits [bacterial inhibitory activity] and suggests that it might function as a [drug depot], releasing ciprofloxacin over time. This research offers a novel perspective on the [pharmacokinetic] profile of ciprofloxacin and its potential to provide prolonged antibacterial activity.

Ciprofloxacin Precipitate: A [Unexpected Twist] in Drug Delivery

This research unveils a fascinating [pharmacokinetic] phenomenon with ciprofloxacin ophthalmic solution. The study reveals that the white precipitate formed on the corneal surface [acts as a drug depot], prolonging the drug's [antibacterial effect]. This finding challenges traditional understanding of drug delivery and suggests that the precipitate could play a significant role in optimizing ciprofloxacin's [therapeutic efficacy].

Understanding the [Unforeseen Consequences] of Drug Delivery

This research underscores the importance of understanding the [complexities] of drug delivery and its potential [unforeseen consequences]. The study highlights how a seemingly [insignificant precipitate] can [alter] the [pharmacokinetic profile] of a drug and significantly impact its [therapeutic efficacy]. This research emphasizes the need for [comprehensive analysis] to understand the full spectrum of [drug delivery mechanisms] and ensure the safe and effective use of medications.

Dr. Camel's Conclusion

This research reveals a [hidden layer] in the [pharmacokinetic] profile of ciprofloxacin. The white precipitate formed on the corneal surface acts as an [unexpected drug depot], prolonging the drug's [antibacterial effect]. This finding underscores the importance of understanding the [complexities] of drug delivery and its potential [unforeseen consequences]. Just as a [camel's hump] stores energy for long desert journeys, this precipitate serves as a [reservoir] for ciprofloxacin, ensuring its sustained antibacterial activity.
Date :
  1. Date Completed 1999-10-13
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

10487428

DOI: Digital Object Identifier

00003226-199909000-00004

Related Literature

Article Analysis
・Effects of ciprofloxacin ophthalmic
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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