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Interactions of hydrated IIa and IIb group metal cations with thioguanine-cytosine DNA base pair: Ab initio and density functional theory investigation of polarization effects, differences among cations, and flexibility of the cation hydration shell.

Author: BurdaJ V, HobzaP, LeszczynksiJ, SponerJ

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

The structures and energies of the thioguanine-cytosine Watson-Crick (thioGC WC) base pair interacting with hydrated IIa (Mg2+, Ca2+, Ba2+) and IIb group (Zn2+, Cd2+, Hg2+) cations have been studied using ab initio techniques. The complexes of the thioGC WC base pair with hydrated cations have similar properties as the previously studied GC WC base pair. Soft Cd2+ and Hg2+ cations have a uniquely strong interaction with the thiogroup and induce substantial nonplanarity of the pairing.
Paper Details　
Original Abstract of the Article :
The structures and energies of the thioguanine-cytosine Watson-Crick (thioGC WC) base pair interacting with hydrated IIa (Mg2+, Ca2+, Ba2+) and IIb group (Zn2+, Cd2+, Hg2+) cations have been studied using ab initio techniques. Furthermore, complexes between guanine and thioguanine with hydrated cati...See full text at original site
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引用元：
https://doi.org/10.1080/07391102.1999.10508341

データ提供：米国国立医学図書館（NLM）

Metal Cations and DNA Base Pair Interactions

The fascinating world of molecular interactions is always a source of scientific exploration. This study investigates the interactions between hydrated metal cations and the thioguanine-cytosine DNA base pair. Imagine these molecules as tiny desert nomads, each with unique properties and tendencies to interact with their environment.

Metal Cations and DNA

The research delves into the intricate dance between metal cations and the DNA base pair, highlighting the role of polarization and hydration in influencing these interactions. It's like a desert oasis where the presence of water can dramatically alter the behavior of the surrounding environment. The study explores how different metal cations, like magnesium and zinc, interact differently with the DNA base pair, offering a deeper understanding of these fundamental molecular processes.

The Importance of Molecular Interactions

Understanding the interactions between metal cations and DNA is crucial for comprehending biological processes at the molecular level. It's like studying the interactions between different plants and animals in a desert ecosystem—understanding these relationships is essential for comprehending the overall dynamics of the environment. This research provides valuable insights into the fundamental mechanisms of life at the molecular level.

Dr.Camel's Conclusion

This study provides a fascinating glimpse into the intricate dance between metal cations and DNA. It's like watching a desert nomad carefully navigate a sandstorm, adapting to the ever-changing environment. The researchers' findings offer a deeper understanding of these fundamental interactions, paving the way for further exploration and discovery in the realm of molecular biology.

Date :
  1. Date Completed 1999-11-22
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

10496422

DOI: Digital Object Identifier

10.1080/07391102.1999.10508341

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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