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Detailed examination of fenfluramine-phentermine users with valve abnormalities identified in Fargo, North Dakota.

Author: BeareJ, CraryJ L, JonesJ, KeaneM G, KimmelS E, KinmanJ L, SammelM, StromB L, SuttonM S

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study was a detailed medical record review of 18 previously reported users of fenfluramine and phentermine, all with valve abnormalities on echocardiogram. Two subjects had other possible etiologies of valve disease. Use of medications that may affect serotonin receptors was common. This study raises the hypotheses that valvular heart disease among fenfluramine users may be less common than previously estimated, that serotonin excess may play a role in valve pathology, and that a patient's response to anorexigens and other medications may serve as a marker for increased risk.
Paper Details　
Original Abstract of the Article :
Although several studies have reported on valve abnormalities among users of fenfluramine or dexfenfluramine, detailed information on these subjects has not been provided, limiting the ability to understand who may be at risk for valve abnormalities and to generate hypotheses about the etiology and ...See full text at original site
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引用元：
https://doi.org/10.1016/s0002-9149(99)00281-7

データ提供：米国国立医学図書館（NLM）

Investigating Valve Abnormalities in Fenfluramine-Phentermine Users

This research delves into the potential link between fenfluramine and phentermine use and the development of valve abnormalities. The study involved a detailed medical record review of individuals who had previously used these medications and were diagnosed with valve abnormalities. The researchers analyzed clinical characteristics and medication use to understand the potential risk factors and mechanisms behind this association.

Potential Role of Serotonin Excess in Valve Pathology

The study findings suggest a possible link between serotonin excess and valve pathology. While other potential causes of valve disease were identified in some individuals, the prevalence of medications that affect serotonin receptors among the subjects raised concerns about the role of serotonin in this phenomenon. The study also highlights the importance of considering patient's response to anorexigens and other medications as a potential marker for increased risk.

Understanding the Potential Risks of Weight-Loss Medications

Think of it this way: Imagine a camel caravan carrying precious spices across the desert. Some camels might be more sensitive to certain types of food and water, just as some individuals may have a greater sensitivity to particular medications. This research underscores the importance of considering individual factors and potential risks associated with weight-loss medications, especially those that affect serotonin levels.

Dr. Camel's Conclusion

This study sheds light on the potential role of serotonin excess in the development of valve abnormalities in fenfluramine-phentermine users. It emphasizes the need for careful evaluation of potential risks and individualized treatment plans, ensuring that the journey towards weight loss is safe and healthy for all.

Date :
  1. Date Completed 1999-09-28
  2. Date Revised 2019-06-22
Further Info :

Pubmed ID

10496440

DOI: Digital Object Identifier

10.1016/s0002-9149(99)00281-7

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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