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Hydroxyurea in the treatment of HIV-1 infection: toxicity and side effects.

Author: MaseratiR

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Hydroxyurea, when administered at 1000 mg/day in asymptomatic HIV-infected patients, was generally well tolerated with rare, reversible episodes of cytopenia. Long therapy courses, up to 3 years, have not shown significant toxicity.
Paper Details　
Original Abstract of the Article :
Hydroxyurea has been used in numerous clinical trials for the treatment of HIV-1 infection, almost always in combination with didanosine with or without other antiretrovirals. Due to its inhibition of DNA synthesis, the main side effect of hydroxyurea is myelosuppression. When administered at the do...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/10560753

データ提供：米国国立医学図書館（NLM）

Hydroxyurea: A Potential Treatment for HIV-1 Infection with Considerations for Toxicity

This review examines the use of hydroxyurea in the treatment of HIV-1 infection, focusing on its toxicity and side effects. The authors discuss the use of hydroxyurea in clinical trials, primarily in combination with didanosine and other antiretrovirals. They highlight the main side effect, myelosuppression, and its potential implications.

Hydroxyurea: Benefits and Risks

The review indicates that hydroxyurea, when administered at appropriate doses, has a favorable tolerability profile in asymptomatic, moderately immunosuppressed HIV-1-infected patients. However, higher doses and use in advanced patients may increase the risk of more severe side effects.

Managing HIV-1 Infection

This review provides valuable information for clinicians managing HIV-1 infection. It highlights the importance of carefully considering the benefits and risks associated with hydroxyurea, ensuring safe and effective treatment.

Dr.Camel's Conclusion

Like a camel carefully navigating a desert oasis, we must approach hydroxyurea treatment with a mindful balance, weighing its potential benefits against its potential risks. This review provides crucial insights into the use of hydroxyurea in HIV-1 infection, guiding us towards safer and more effective treatment strategies.

Date :
  1. Date Completed 1999-11-23
  2. Date Revised 2007-11-15
Further Info :

Pubmed ID

10560753

DOI: Digital Object Identifier

10560753

Related Literature

Article Analysis
・Side Effects of hydroxyurea
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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