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An open-label study of repeated use of diazepam rectal gel (Diastat) for episodes of acute breakthrough seizures and clusters: safety, efficacy, and tolerance. North American Diastat Group.

Author: CereghinoJ J, ConryJ A, CrumrineP K, GrovesL, KrielR L, MitchellW G, RosenfeldW E

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Diazepam rectal gel is a safe and effective treatment for acute seizures in epilepsy patients, with no significant tolerance or medication-related adverse effects seen with repeated use.
Paper Details　
Original Abstract of the Article :
PURPOSE: To assess safety of diazepam rectal gel (DZPRG) for control of acute seizures in epilepsy patients and to evaluate tolerance with repeated use of DZPRG at intervals of > or =5 days. METHODS: Subjects were persons with epilepsy, age 2 years or older, with seizure clusters or prolonged seizu...See full text at original site
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引用元：
https://doi.org/10.1111/j.1528-1157.1999.tb02047.x

データ提供：米国国立医学図書館（NLM）

Diazepam Rectal Gel: A Reliable Oasis in the Desert of Breakthrough Seizures

We're trekking through the [Epilepsy] desert, a landscape where seizures can disrupt lives and create challenges for both patients and caregivers. This research explores the use of diazepam rectal gel (DZPRG) as a treatment for acute breakthrough seizures and clusters. It's like finding a reliable oasis in the desert, offering a safe and effective solution for those facing sudden and unpredictable seizures.

Diazepam Rectal Gel: A Powerful Tool for Managing Breakthrough Seizures

The study found that DZPRG was safe and effective in treating acute seizures in epilepsy patients, providing a much-needed respite for those experiencing seizures. It's like discovering a well-stocked oasis, offering a safe and reliable haven for individuals facing this debilitating condition. The authors found that DZPRG could be used repeatedly without developing tolerance or significant side effects, making it a valuable tool for managing breakthrough seizures.

Navigating the Desert of Epilepsy

This research provides valuable insights into the management of breakthrough seizures. DZPRG, with its safety and efficacy, offers a potential oasis for individuals facing this challenging condition. It's a reminder that in the desert of epilepsy, we can find innovative solutions and reliable tools to navigate the unpredictable landscape of seizures. As with any oasis, it's crucial to consult with a healthcare professional for personalized guidance and ensure safe and effective use.

Dr.Camel's Conclusion

This study sheds light on the potential of diazepam rectal gel as a safe and effective treatment for breakthrough seizures in epilepsy patients. It's a reminder that in the desert of epilepsy, we can find valuable tools to manage these challenging conditions and improve quality of life. DZPRG, like a reliable oasis, offers a safe and effective solution for those seeking relief from sudden and unpredictable seizures.

Date :
  1. Date Completed 1999-11-26
  2. Date Revised 2019-08-13
Further Info :

Pubmed ID

10565590

DOI: Digital Object Identifier

10.1111/j.1528-1157.1999.tb02047.x

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・Effects of diazepam rectal
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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