Low convulsive activity of a new carbapenem antibiotic, DK-35C, as compared with existing congeners.

Author: ChoJ H, JinC, JungI, KimD H, KimM, KuH J, OhC H, YookJ

Paper Details 
Original Abstract of the Article :
Since carbapenems and cephalosporins have been suggested to induce convulsive side effects through an inhibitory action on the central gamma-aminobutyric acid (GABA)-mediated inhibitory transmission, the present study evaluated the convulsive activity of a new carbapenem antibiotic (1R,5S,6S)-6[(R)-...See full text at original site
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引用元:
https://doi.org/10.1016/s0300-483x(99)00078-5

データ提供:米国国立医学図書館(NLM)

Exploring the Safety of a New Carbapenem Antibiotic

The world of antibiotics is vast and complex, just like a desert with hidden oases and potential dangers. This study investigates the convulsive activity of a new carbapenem antibiotic, DK-35C, comparing it to existing congeners. Carbapenems are a class of antibiotics known for their broad-spectrum activity, but they can also have side effects, such as seizures.

Researchers, like explorers venturing into a new territory, sought to understand the safety profile of this new antibiotic. They compared the convulsive activity of DK-35C to other carbapenems, hoping to find a balance between effectiveness and safety.

Navigating the Desert of Antibiotic Safety

The study found that DK-35C had a relatively low convulsive activity compared to other carbapenems. This is a promising finding, as it suggests that DK-35C could potentially be a safer alternative for patients who are susceptible to seizures. It's like finding a safe and reliable path through a desert riddled with treacherous sandstorms.

Finding a Balance Between Effectiveness and Safety

This research highlights the importance of finding a balance between effectiveness and safety in antibiotic development. Just as a camel needs a balance of resources to survive in the desert, so too do patients need medications that are both effective and safe.

Dr.Camel's Conclusion

This study explores the safety profile of a new carbapenem antibiotic, DK-35C. The findings suggest that DK-35C has a relatively low convulsive activity compared to existing congeners. This is a promising discovery, as it offers a potential solution for patients who are susceptible to seizures. The study emphasizes the importance of navigating the desert of antibiotic safety with caution, seeking a balance between effectiveness and minimal side effects.

Date :
  1. Date Completed 1999-12-10
  2. Date Revised 2019-08-19
Further Info :

Pubmed ID

10576583

DOI: Digital Object Identifier

10.1016/s0300-483x(99)00078-5

Related Literature

SNS
PICO Info
in preparation
Languages

English

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