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Intensification of the stem cell transplant induction regimen results in increased treatment-related mortality without improved outcome in multiple myeloma.

Author: AbrahamR, ChenC, CrumpR M, DavidsonM, KeatingA, MeharchandJ, MurrayC, SimpsonD, StewartA K, SuttonD M, TsangR

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This study investigated the use of an intensified stem cell transplantation (SCT) regimen in patients with multiple myeloma (MM), utilizing escalated melphalan and fractionated total body irradiation, as well as etoposide. While this regimen increased morbidity and mortality, it did not significantly improve overall survival compared to less toxic regimens.
Paper Details　
Original Abstract of the Article :
Randomized trials conducted by the Intergroupe Française du Myelome (IFM) demonstrate that the use of high-dose chemotherapy (HDCT) and stem cell transplantation (SCT) improves event-free (EFS) and overall survival (OS) in younger patients with multiple myeloma (MM). Nevertheless, current HDCT regim...See full text at original site
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引用元：
https://doi.org/10.1038/sj.bmt.1702060

データ提供：米国国立医学図書館（NLM）

Intensifying Stem Cell Transplant for Multiple Myeloma: A Balancing Act

The field of hematology is constantly seeking ways to improve treatment outcomes for patients with multiple myeloma (MM), a challenging type of blood cancer. This research explores the potential of intensifying the stem cell transplant induction regimen, a cornerstone of MM treatment. The authors investigated the impact of an escalated regimen incorporating high-dose melphalan, fractionated total body irradiation, and etoposide on treatment-related mortality and overall survival. The study reveals a complex trade-off between enhanced treatment efficacy and increased risks, reminding us that the quest for optimal treatment is a delicate balancing act.

Intensification Increases Morbidity but Not Overall Survival

The study found that intensifying the stem cell transplant induction regimen led to increased treatment-related mortality, particularly due to interstitial pneumonitis. However, the study did not demonstrate a significant improvement in overall survival. This finding emphasizes the importance of carefully considering the risks and benefits of intensified treatment strategies.

Navigating the Complexities of Cancer Treatment

This research reminds us that cancer treatment is not always a simple path. The quest for optimal treatment often involves balancing the potential for improved outcomes with the risks of adverse effects. Understanding the individual patient's profile and carefully weighing the risks and benefits is crucial in guiding treatment decisions.

Dr.Camel's Conclusion

The desert is a harsh environment, and so is the battle against cancer. This research reminds us that even the most promising treatment strategies may come with unexpected consequences. Finding the right balance between aggression and caution is essential in the fight against cancer. This study highlights the need for ongoing research to refine treatment strategies and minimize risks for patients.

Date :
  1. Date Completed 2000-02-23
  2. Date Revised 2019-12-10
Further Info :

Pubmed ID

10627637

DOI: Digital Object Identifier

10.1038/sj.bmt.1702060

Related Literature

Article Analysis
・Effective treatment of multiple myeloma
SNS
PICO Info
in preparation
Languages

English

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