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Inhibitory effects of trospium chloride on cytochrome P450 enzymes in human liver microsomes.

Author: Beckmann-KnoppS, BeckurtsK T, BöckerR H, FuhrU, LangW, RietbrockS, WeyhenmeyerR

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Trospium chloride has negligible inhibitory effects on CYP3A4, CYP1A2, CYP2E1, CYP2C19, CYP2C9 and CYP2A6 activity but is a reasonably potent inhibitor of CYP2D6 in vitro. However, inhibition of CYP2D6 by trospium chloride is without any clinical relevance.
Paper Details　
Original Abstract of the Article :
Trospium chloride, an atropine derivative used for the treatment of urge incontinence, was tested for inhibitory effects on human cytochrome P450 enzymes. Metabolic activities were determined in liver microsomes from two donors using the following selective substrates: dextromethorphan (CYP2D6), den...See full text at original site
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引用元：
https://doi.org/10.1111/j.1600-0773.1999.tb02026.x

データ提供：米国国立医学図書館（NLM）

Trospium Chloride: A Journey Through the Desert of Drug Interactions

The desert of pharmacology is full of complex interactions between different drugs. This study investigates the potential interactions of trospium chloride, a medication used to treat urge incontinence, with various cytochrome P450 enzymes, which are critical for metabolizing drugs in the body.

Trospium Chloride: A Gentle Breeze in the Desert of Drug Interactions

The study found that trospium chloride had minimal impact on most cytochrome P450 enzymes, except for a moderate inhibitory effect on CYP2D6. This suggests that trospium chloride is unlikely to significantly affect the metabolism of most drugs, providing a sense of relief in the complex landscape of drug interactions. It's like finding a gentle breeze in the desert, offering a sense of calm amidst the chaos of potential drug interactions.

Navigating the Desert of Drug Interactions: A Guide for Healthcare Professionals

This research provides valuable insights for healthcare professionals, helping them navigate the complex desert of drug interactions. The study highlights the importance of understanding the potential interactions of medications, particularly those affecting cytochrome P450 enzymes. It's like having a map in the desert, providing a sense of direction and guidance for avoiding potential pitfalls.

Dr.Camel's Conclusion

This study sheds light on the potential interactions of trospium chloride with cytochrome P450 enzymes, offering a glimpse into the intricate landscape of drug interactions. While trospium chloride appears to have minimal impact on most enzymes, its moderate inhibitory effect on CYP2D6 underscores the importance of careful consideration when prescribing medications.
Date :
  1. Date Completed 2000-01-20
  2. Date Revised 2019-09-05
Further Info :

Pubmed ID

10628907

DOI: Digital Object Identifier

10.1111/j.1600-0773.1999.tb02026.x

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in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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