Acyclovir for treatment of infectious mononucleosis: a meta-analysis.

Author: TambiniR, TorreD

Paper Details 
Original Abstract of the Article :
A meta-analysis of 5 randomized controlled trials (RCT), involving 339 patients with acute infectious mononucleosis (IM) treated with acyclovir (ACV) was performed. ACV was given intravenously in 2 RCTs, which included patients with more severe disease, and orally in the remaining 3 RCTs, which incl...See full text at original site
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引用元:
https://doi.org/10.1080/00365549950164409

データ提供:米国国立医学図書館(NLM)

Acyclovir for Mononucleosis: A Comprehensive Review

This meta-analysis delves into the effectiveness of acyclovir, an antiviral medication, in treating infectious mononucleosis (IM), a common viral infection caused by the Epstein-Barr virus (EBV). The researchers pooled data from five randomized controlled trials (RCTs) to assess the clinical and virological effects of acyclovir in patients with IM.

The analysis revealed that while acyclovir did not demonstrate statistically significant clinical benefits, it did significantly reduce the rate of EBV shedding from the throat. However, this reduction was only observed during the treatment period and did not persist after treatment ended. The study also found no significant difference in adverse events between the acyclovir and placebo groups.

The study highlights the need for further research to develop more effective treatments for EBV infection.

Acyclovir: A Step in the Right Direction?

The meta-analysis suggests that while acyclovir may reduce viral shedding during treatment, it doesn't offer substantial clinical benefit for IM. This emphasizes the need for continued research to develop more effective treatments for this common viral infection.

Navigating the Desert of Viral Infections: What This Means for You

If you are diagnosed with IM, it's important to consult with your doctor about appropriate treatment options. While acyclovir may provide some benefit in reducing viral shedding, it's not a guaranteed cure. Remember, taking care of your body by getting enough rest, staying hydrated, and managing your symptoms is crucial in fighting off viral infections.

Dr.Camel's Conclusion

This meta-analysis, while not finding a clear-cut solution for IM, offers valuable insights into the complexities of treating viral infections. It highlights the need for continued research and development of more effective antiviral therapies. Remember, in the desert of viral infections, knowledge is power, and staying informed about the latest research and treatment options can help us navigate these challenges.

Date :
  1. Date Completed 2000-03-02
  2. Date Revised 2019-08-26
Further Info :

Pubmed ID

10680982

DOI: Digital Object Identifier

10.1080/00365549950164409

Related Literature

SNS
PICO Info
in preparation
Languages

English

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