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Effects of oral clonidine premedication on side effects of intravenous ketamine anesthesia: a randomized, double-blind, placebo-controlled study.

Author: HandaF, NishikawaT, TanakaM, ToyookaH

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Oral clonidine premedication effectively attenuated the cardiostimulatory effects of ketamine anesthesia. Clonidine 5 micrograms/kg was associated with a reduced incidence of nightmares and salivation.
Paper Details　
Original Abstract of the Article :
STUDY OBJECTIVE: To determine the effects of oral clonidine premedication on hemodynamic changes during the entire course of ketamine anesthesia and incidence of postoperative adverse reactions. DESIGN: Randomized, prospective, double-blind, placebo-controlled study. SETTING: Department of Anesthe...See full text at original site
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引用元：
https://doi.org/10.1016/s0952-8180(99)00131-2

データ提供：米国国立医学図書館（NLM）

Clonidine: A Oasis in the Desert of Ketamine Anesthesia

This research explores the use of clonidine as a premedication for patients undergoing ketamine anesthesia. Imagine a traveler preparing for a journey through a challenging desert, seeking ways to mitigate the potential side effects of the journey.

Mitigating the Rough Terrain: Clonidine's Effects on Ketamine Anesthesia

The study investigates the effects of clonidine on hemodynamic changes and postoperative adverse reactions associated with ketamine anesthesia. It's like discovering a hidden oasis that can help travelers prepare for the potential bumps and rough patches along the way. The study found that clonidine effectively attenuates the heart-stimulating effects of ketamine, potentially reducing the risk of unwanted side effects.

Navigating the Desert of Anesthesia: A Smoother Journey

The study also found that clonidine premedication significantly reduced the incidence of nightmares and excessive salivation, common side effects of ketamine anesthesia. It's like discovering a smoother path through the desert, one that allows travelers to enjoy their journey with fewer interruptions and discomfort. This research provides valuable insights for optimizing the use of ketamine anesthesia and ensuring a more comfortable experience for patients.

Dr. Camel's Conclusion

This research is like discovering a hidden oasis in the vast desert of anesthesia. Clonidine, when used as a premedication, offers a potential solution to reduce the undesirable side effects of ketamine anesthesia. It's a testament to the ongoing research that seeks to make medical procedures safer and more comfortable for patients.

Date :
  1. Date Completed 2000-07-06
  2. Date Revised 2019-09-15
Further Info :

Pubmed ID

10773503

DOI: Digital Object Identifier

10.1016/s0952-8180(99)00131-2

Related Literature

Article Analysis
・Side Effects of clonidine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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