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The case for an individual approach to the treatment of depression.

Author: HealyD

ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Antidepressants are likely to have different treatment effect sizes in different constitutional types. Their efficacy may stem from their ability to suppress symptoms and elicit or maintain conditions that allow recovery in a subgroup of patients.
Paper Details　
Original Abstract of the Article :
Early reports of the discovery of antidepressants in the 1950s have remained as little-known findings. Had the discovery of isoniazid, an agent with no clear action on monoamine systems, and that of reserpine, which depletes monoamines, been more widely known, then the monoamine lesion theories of d...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/10775020

データ提供：米国国立医学図書館（NLM）

The Case for an Individual Approach to the Treatment of Depression

This study explores the challenges and complexities of treating depression, questioning the effectiveness of a one-size-fits-all approach based on monoamine theories. The researchers examine the historical context of antidepressant discovery and propose an alternative approach, advocating for individualized treatment strategies tailored to specific constitutional types.

Constitutional Types and Antidepressant Selectivity

The researchers argue that antidepressants may have different treatment effect sizes in different constitutional types. They suggest that antidepressants may act on these types to provide appropriate therapeutic principles, suppressing symptoms and promoting recovery in a subgroup of patients. The study proposes that different antidepressants may embody different therapeutic principles, such as 'get-up-and-go' (noradrenergic) or emotional reactivity-reducing (serotonergic) principles.

Tailoring Treatment to Individuals

This study underscores the importance of individualizing treatment for depression, recognizing the diverse nature of the condition and the unique responses to different medications. It's like a camel caravan encountering a variety of terrains – each camel requires specific care based on its individual strengths and weaknesses. The researchers advocate for a personalized approach to treatment, considering individual needs and constitutional types.

Dr. Camel's Conclusion

This research underscores the need for personalized treatment approaches for depression, recognizing the diverse nature of the condition and the unique responses to different medications. It's like a camel caravan navigating a vast and varied desert – each camel requires specific care based on its individual strengths and weaknesses. The researchers advocate for a personalized approach to treatment, considering individual needs and constitutional types.

Date :
  1. Date Completed 2000-04-26
  2. Date Revised 2022-12-07
Further Info :

Pubmed ID

10775020

DOI: Digital Object Identifier

10775020

Related Literature

Article Analysis
・Side Effects of reserpine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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