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Simultaneous determination of the HIV protease inhibitors indinavir, amprenavir, saquinavir, ritonavir, nelfinavir and the non-nucleoside reverse transcriptase inhibitor efavirenz by high-performance liquid chromatography after solid-phase extraction.
Author: BiollazJ, BuclinT, DecosterdL A, MarzoliniC, TelentiA
Original Abstract of the Article :
As part of an on-going study on the suitability of a formal therapeutic drug monitoring (TDM) of antiviral drugs for improving the management of HIV infection, a high-performance liquid chromatography method has been developed to quantify simultaneously in plasma five HIV protease inhibitors (PIs) (...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1016/s0378-4347(99)00573-3
データ提供:米国国立医学図書館(NLM)
HIV Drug Monitoring: A Desert of Complexity, a Journey of Precision
This research delves into the complex world of HIV treatment, focusing on the development of a high-performance liquid chromatography (HPLC) method for simultaneously quantifying five HIV protease inhibitors (PIs) and the non-nucleoside reverse transcriptase inhibitor efavirenz in plasma. It's like navigating the vast and intricate desert of HIV therapy, where precise drug monitoring is crucial for optimal patient outcomes.
A New Oasis of Monitoring: A Precise Path to Treatment
The researchers developed a sensitive and accurate HPLC method for quantifying these antiretroviral drugs. This method provides a valuable tool for clinicians, allowing them to monitor drug levels in patients and ensure that they are receiving adequate doses. It's like discovering a hidden oasis in the desert of HIV treatment, where precise monitoring can lead to better patient outcomes.
The Journey Towards Wellness: Navigating the Desert of HIV
This research highlights the importance of therapeutic drug monitoring in optimizing HIV treatment. It's a reminder that the journey through the desert of HIV requires a multifaceted approach, including careful monitoring of drug levels, adherence to treatment regimens, and a collaborative relationship between patients and healthcare providers.
Dr. Camel's Conclusion
This research offers a significant advancement in the field of HIV treatment. By developing a precise and reliable method for monitoring drug levels, we can create a more effective and personalized approach to managing this complex condition.
Date :
- Date Completed 2000-06-23
- Date Revised 2020-12-08
Further Info :
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