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Comparison of the effects of zaleplon, zolpidem, and triazolam on memory, learning, and psychomotor performance.

Author: CevallosW H, FurlanP M, LeisterC A, LuckiI, ManganoR, MartinP T, TroyS M, UnruhM A

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Zaleplon is a safe hypnotic that does not affect memory, learning, or psychomotor skills associated with vigilance.
Paper Details　
Original Abstract of the Article :
Twenty-four healthy male and female subjects, who participated in this randomized, double-blind, crossover study, received single nighttime doses of zaleplon 10 mg (therapeutic dose), zaleplon 20 mg, zolpidem 10 mg (therapeutic dose), zolpidem 20 mg, triazolam 0.25 mg (positive control), and placebo...See full text at original site
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引用元：
https://doi.org/10.1097/00004714-200006000-00007

データ提供：米国国立医学図書館（NLM）

Hypnotics: Navigating the Landscape of Sleep and Cognition

In the quest for restful sleep, hypnotics are often employed, but their impact on cognitive function can be a concern. This research delves into the effects of three hypnotics - zaleplon, zolpidem, and triazolam - on memory, learning, and psychomotor performance. The study used a randomized, double-blind, crossover design to compare the effects of these medications at different doses.

Zaleplon: A Potential Winner in the Sleep and Cognition Race

The study found that zaleplon, at its therapeutic dose (10mg), had no significant impact on memory or learning compared to placebo. However, other hypnotics, including zolpidem and triazolam, did impair psychomotor performance. The study also revealed that zaleplon's effects on cognition were transient and dissipated within 8.25 hours.

Hypnotics: Choosing the Right Path for Restful Sleep

This research underscores the importance of choosing hypnotics carefully, considering their potential impact on cognitive function. Zaleplon, at its therapeutic dose, appears to be a promising option for those seeking sleep without significant cognitive impairment. However, further research is needed to confirm its long-term effects and safety.

Dr. Camel's Conclusion

This study reminds us that the desert of sleep medication can be a tricky landscape to navigate! Zaleplon seems to offer a safe and effective path to restful sleep, but as always, it's crucial to be mindful of the potential effects on cognition and to consult with your healthcare provider to make informed decisions. Remember, a well-rested camel is a happy camel!

Date :
  1. Date Completed 2000-09-01
  2. Date Revised 2019-09-10
Further Info :

Pubmed ID

10831020

DOI: Digital Object Identifier

10.1097/00004714-200006000-00007

Related Literature

Article Analysis
・Effects of zaleplon
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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