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Internal sphincterotomy is superior to topical nitroglycerin in the treatment of chronic anal fissure: results of a randomized, controlled trial by the Canadian Colorectal Surgical Trials Group.

Author: BuieD, BurnsteinM, BurulC, GregoireR, McLeodR S, MukrajD, O'ConnorB I, PlewesE A, ReznickR, RichardC S, RossT, SilvermanR

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Internal sphincterotomy is superior to topical nitroglycerin for the treatment of chronic anal fissure. The healing rate was higher, side effects were fewer, and the risk of early incontinence was lower with internal sphincterotomy.
Paper Details　
Original Abstract of the Article :
PURPOSE: This was a multicenter, randomized, controlled trial to compare the effectiveness of topical nitroglycerin with internal sphincterotomy in the treatment of chronic anal fissure. METHODS: Patients with symptomatic chronic anal fissures were randomly assigned to 0.25 percent nitroglycerin ti...See full text at original site
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引用元：
https://doi.org/10.1007/BF02236548

データ提供：米国国立医学図書館（NLM）

Internal Sphincterotomy: A Superior Treatment for Chronic Anal Fissure

This study delves into the realm of colorectal surgery, comparing the effectiveness of internal sphincterotomy with topical nitroglycerin in treating chronic anal fissure. The researchers conducted a multicenter, randomized, controlled trial involving 90 patients with chronic anal fissure. The results demonstrated that internal sphincterotomy was significantly more effective in achieving complete healing of the fissure, with a much lower relapse rate and fewer side effects compared to topical nitroglycerin.

A Clear Choice for Anal Fissure Treatment

This research provides strong evidence for the superiority of internal sphincterotomy over topical nitroglycerin in treating chronic anal fissure. The study's findings highlight the effectiveness of surgical intervention in achieving long-term healing, minimizing relapse, and reducing the incidence of side effects. These results suggest that internal sphincterotomy should be considered the preferred treatment option for chronic anal fissure.

Improving Patient Outcomes

This research is a significant step forward in improving patient outcomes for chronic anal fissure. The study's findings provide clear guidance for clinicians, demonstrating the effectiveness of internal sphincterotomy in achieving complete healing and reducing the need for repeat treatments. By adopting these evidence-based practices, we can provide more effective and patient-centered care for individuals suffering from chronic anal fissure.

Dr. Camel's Conclusion

This research is a journey through the labyrinth of colorectal surgery, revealing the most effective path to healing for those suffering from chronic anal fissure. The researchers have discovered that internal sphincterotomy is a more efficient camel caravan, leading to faster and more sustainable healing. Their findings remind us that the pursuit of medical advancements is a continuous journey, requiring ongoing exploration and innovation to improve patient well-being.

Date :
  1. Date Completed 2000-09-01
  2. Date Revised 2019-07-21
Further Info :

Pubmed ID

10950002

DOI: Digital Object Identifier

10.1007/BF02236548

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English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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