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Virological and immunological effects of combination antiretroviral therapy with zidovudine, lamivudine, and indinavir during primary human immunodeficiency virus type 1 infection.
Author: BerreyM M, BurckhardtB, ClumeckN, CooperD A, CoreyL, LazzarinA, MarkowitzM, MehrotraD, PerrinL, RobertsonM, SmithD, WeberR
Original Abstract of the Article :
Forty-seven patients presenting with primary human immunodeficiency virus (HIV) infection were treated with zidovudine 200 mg 3 times a day, lamivudine 150 mg 2 times a day, and indinavir 800 mg 3 times a day for 1 year. From a mean pretreatment viral RNA level of 4.93 log(10) copies/mL, the proport...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
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引用元:
https://doi.org/10.1086/315753
データ提供:米国国立医学図書館(NLM)
Combination Antiretroviral Therapy for Primary HIV Infection: A Year of Progress
Human immunodeficiency virus (HIV) infection remains a significant global health challenge, requiring effective treatment strategies to manage the virus and improve patient outcomes. This study investigates the virological and immunological effects of combination antiretroviral therapy (cART) with zidovudine, lamivudine, and indinavir in patients with primary HIV infection. Researchers followed 47 patients receiving cART for one year, meticulously monitoring their viral load, CD4 cell counts, and overall health. The study's findings demonstrate the efficacy of cART in suppressing viral replication and promoting immune recovery in patients with primary HIV infection, offering valuable insights into the long-term benefits of early treatment.
Combination Therapy: A Powerful Weapon Against HIV Infection
The study highlights the efficacy of cART in suppressing viral replication in patients with primary HIV infection. The majority of patients achieved undetectable viral loads within the first year of treatment, demonstrating the effectiveness of this therapeutic approach in controlling HIV infection. Additionally, the study observed a significant increase in CD4 cell counts, indicating the restoration of immune function. The findings emphasize the importance of early initiation of cART in achieving long-term viral suppression and promoting immune recovery in patients with HIV.
Navigating HIV Infection: Seeking Comprehensive Care and Support
If you are diagnosed with HIV infection, seek comprehensive medical care and support. Early initiation of cART, as demonstrated in this study, is crucial for controlling the virus and preventing long-term complications. Working closely with healthcare professionals and support groups can provide you with the necessary resources and guidance for managing your condition effectively and living a fulfilling life.
Dr. Camel's Conclusion
This study, like a desert oasis providing respite for those battling HIV infection, highlights the effectiveness of combination therapy in suppressing viral replication and promoting immune recovery. Early initiation of cART offers a beacon of hope for patients with HIV, potentially leading to a healthier and more fulfilling life. It emphasizes the power of medical innovation in fighting this formidable disease.
Date :
- Date Completed 2000-11-03
- Date Revised 2013-11-21
Further Info :
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