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In vitro and in vivo antibacterial activities of a new injectable carbapenem, S-4661, against gynaecological pathogens.

Author: HayasakiY, HuaY X, IzumiK, MikamoH, SatoY, TamayaT

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

S-4661, a new injectable carbapenem antibiotic, was found to be effective against strains of bacteria that commonly cause infections in obstetrics and gynecology. S-4661 was also effective in treating pyometra, a uterine infection, in a rat model.
Paper Details　
Original Abstract of the Article :
Carbapenems are often used to treat infections in obstetrics and gynaecology because of their activity against anaerobes. S-4661, a new injectable carbapenem antibiotic, has favourable pharmacokinetic properties and is not hydrolysed by dehydropeptidase I. We investigated the in vitro and in vivo an...See full text at original site
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引用元：
https://doi.org/10.1093/jac/46.3.471

データ提供：米国国立医学図書館（NLM）

S-4661: A New Injectable Carbapenem Against Gynecological Pathogens

This study investigates the antibacterial activity of S-4661, a new injectable carbapenem antibiotic, against gynecological pathogens. The authors conducted in vitro and in vivo studies to assess S-4661's efficacy against various bacteria commonly involved in gynecological infections. The study aimed to determine the potential of S-4661 as a treatment option for infections in obstetrics and gynecology.

S-4661: A Promising New Antibiotic for Gynecological Infections

The study demonstrated the potent antibacterial activity of S-4661 against a range of gynecological pathogens, including Streptococcus agalactiae, Escherichia coli, Peptostreptococcus magnus, Bacteroides fragilis, and Prevotella bivia. The in vivo efficacy of S-4661 was validated in a rat model of pyometra, demonstrating its effectiveness in treating polymicrobial infections.

S-4661: A Beacon of Hope for Gynecological Infections

This research holds significant promise for the treatment of gynecological infections. The potent antibacterial activity of S-4661 provides a new weapon in the fight against these challenging infections. It's like finding a hidden oasis in the desert, offering a refreshing source of hope and effective solutions for patients.

Dr.Camel's Conclusion

This study highlights the potential of S-4661 as a promising new antibiotic for treating gynecological infections. Its broad-spectrum antibacterial activity and favorable pharmacokinetic properties make it a valuable asset for combating these infections effectively. However, further research is needed to fully assess its clinical efficacy and safety before it can be widely implemented.
Date :
  1. Date Completed 2000-11-28
  2. Date Revised 2019-05-13
Further Info :

Pubmed ID

10980177

DOI: Digital Object Identifier

10.1093/jac/46.3.471

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Languages

English

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