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Deoxyadenosine analogs induce programmed cell death in chronic lymphocytic leukemia cells by damaging the DNA and by directly affecting the mitochondria.

Author: AdachiS, CarreraC J, CarsonD A, ChaoQ, CottamH B, GeniniD, LeoniL M, RoseD W

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

Adenine deoxynucleosides, such as deoxyadenosine and its analogs, induce apoptosis in quiescent lymphocytes and are used to treat indolent lymphoproliferative diseases. This study demonstrated that 2CdA and CaFdA disrupt mitochondrial integrity in chronic lymphocytic leukemia cells, leading to apoptosis.
Paper Details　
Original Abstract of the Article :
Adenine deoxynucleosides induce apoptosis in quiescent lymphocytes and are thus useful drugs for the treatment of indolent lymphoproliferative diseases. To explain why deoxyadenosine and its analogs are toxic to a cell that is not undergoing replicative DNA synthesis, several mechanisms have been pr...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/11071652

データ提供：米国国立医学図書館（NLM）

Deoxyadenosine Analogs: A New Weapon in the Fight Against Chronic Lymphocytic Leukemia

The world of [chronic lymphocytic leukemia (CLL)] is constantly seeking new and effective therapies. This study explores the mechanisms behind the cytotoxic effects of [deoxyadenosine analogs] on CLL cells. The researchers investigated the impact of 2-chloro-2'-deoxyadenosine (2CdA) and 2-chloro-2'-ara-fluorodeoxyadenosine (CaFdA) on CLL cells, focusing on their ability to induce programmed cell death (apoptosis). The study found that these analogs damaged the DNA of CLL cells and directly affected mitochondrial function, ultimately leading to apoptosis. This study contributes to our understanding of the mechanisms underlying the effectiveness of deoxyadenosine analogs in CLL treatment.

Unveiling the Secrets of Apoptosis: Deoxyadenosine Analogs Target DNA and Mitochondria

The study's findings reveal the multifaceted mechanisms by which deoxyadenosine analogs induce apoptosis in CLL cells. By damaging DNA and directly affecting mitochondria, these analogs effectively target key cellular processes involved in cell survival. This knowledge can guide the development of more targeted and effective therapies for CLL.

A New Era of CLL Treatment: Targeting Apoptosis with Deoxyadenosine Analogs

Imagine a world where CLL patients can benefit from therapies that effectively target the disease while minimizing side effects. This research provides valuable insights into the mechanisms of action of deoxyadenosine analogs, paving the way for new and innovative treatments for CLL.

Dr. Camel's Conclusion

Just as a camel can navigate the scorching desert with its remarkable adaptations, deoxyadenosine analogs have the potential to navigate the complex world of CLL, effectively targeting the disease and offering hope for improved patient outcomes. This study underscores the importance of understanding the intricate mechanisms behind drug action, paving the way for new and innovative therapies.

Date :
  1. Date Completed 2001-01-11
  2. Date Revised 2021-02-16
Further Info :

Pubmed ID

11071652

DOI: Digital Object Identifier

S0006-4971(20)48295-3

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