Effect of pamidronate administration on markers of bone turnover and disease activity in multiple myeloma.

Author: AnargyrouK, MeletisJ, PalermosJ, PapassavasP, TerposE, TsionosK, ViniouN, YataganasX

Paper Details 
Original Abstract of the Article :
Bisphosphonates are potent inhibitors of osteoclastic activity and are used in the treatment of multiple myeloma (MM) in combination with chemotherapy. The effect of pamidronate on markers of bone resorption [cross-linked N-telopeptides of type I collagen (NTx)], markers of bone formation [serum alk...See full text at original site
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引用元:
https://doi.org/10.1034/j.1600-0609.2000.065005331.x

データ提供:米国国立医学図書館(NLM)

Effects of Pamidronate on Bone Turnover and Disease Activity in Multiple Myeloma

This research delves into the critical area of treating multiple myeloma, a type of cancer affecting bone marrow. The study investigates the effectiveness of pamidronate, a bisphosphonate, in managing the disease. The researchers employed a comprehensive approach, analyzing the impact of pamidronate on various markers of bone turnover and disease activity in a group of newly diagnosed patients with multiple myeloma. Their findings reveal the potential of pamidronate to regulate bone resorption and formation, as well as its influence on key indicators of disease activity. This study sheds light on the therapeutic role of pamidronate in managing multiple myeloma and offers valuable insights for further research in this field.

Pamidronate Shows Promise in Managing Bone Turnover and Disease Activity in Multiple Myeloma

The study observed a positive effect of pamidronate on key markers of bone resorption, particularly NTx levels, suggesting its ability to slow down bone breakdown. This finding has significant implications for patients with multiple myeloma, as bone disease is a common and debilitating complication. The researchers also noted a reduction in disease-related pain and skeletal events, suggesting that pamidronate might help improve the quality of life for these patients.

Implications for Bone Health and Treatment of Multiple Myeloma

Pamidronate's impact on bone turnover and disease activity in multiple myeloma suggests its potential as a therapeutic agent in managing this challenging cancer. Further research is needed to fully understand its long-term benefits and potential side effects. However, this study offers promising evidence for the potential of pamidronate to improve bone health and alleviate symptoms associated with multiple myeloma.

Dr.Camel's Conclusion

Pamidronate shows promise in managing bone health and disease activity in multiple myeloma. Think of it like a camel with a very specific set of skills – it can effectively navigate the harsh desert landscape of bone turnover in this disease, offering hope for improved quality of life and disease management for these patients. While further research is needed, this study offers a glimpse into the potential benefits of pamidronate for those navigating the challenging journey of multiple myeloma.
Date :
  1. Date Completed 2001-01-04
  2. Date Revised 2019-09-10
Further Info :

Pubmed ID

11092464

DOI: Digital Object Identifier

10.1034/j.1600-0609.2000.065005331.x

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SNS
PICO Info
in preparation
Languages

English

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