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Short-term cotherapy with clonazepam and fluoxetine: anxiety, sleep disturbance and core symptoms of depression.

Author: GlaudinV, LondborgP D, PainterJ R, SmithW T

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study found that combining fluoxetine with clonazepam was safe and accelerated response to treatment in patients with depression. The combination decreased anxiety and sleep disturbance as symptoms and partially suppressed them as SSRI side effects.
Paper Details　
Original Abstract of the Article :
BACKGROUND: SSRIs resolve depression slowly and may increase anxiety or insomnia. Adding clonazepam to fluoxetine sped response, raising the question of mechanism of action: reducing symptoms co-existing with depression, suppressing side-effects, and/or alleviating core depressive symptoms. METHOD:...See full text at original site
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引用元：
https://doi.org/10.1016/s0165-0327(99)00195-0

データ提供：米国国立医学図書館（NLM）

Short-Term Cotherapy with Clonazepam and Fluoxetine

Depression is a complex and debilitating mental health condition. This study investigates the effectiveness of combining clonazepam, a benzodiazepine, with fluoxetine, a selective serotonin reuptake inhibitor (SSRI), for the short-term treatment of depression. The researchers examined the impact of this combination therapy on anxiety, sleep disturbance, and core symptoms of depression in adult outpatients. The results provide insights into the potential benefits of combining these two medications.

Accelerated Response with Cotherapy

The study found that cotherapy with clonazepam and fluoxetine resulted in a significantly faster response rate compared to fluoxetine alone, leading to reductions in anxiety, sleep disturbance, and core depressive symptoms. The combination therapy was also associated with a lower incidence of treatment-emergent anxiety and sleep disturbance compared to placebo.

Managing Depression and Side Effects

This research suggests that low-dose cotherapy with clonazepam and fluoxetine can be a safe and effective approach to managing depression, particularly in cases where anxiety or insomnia are prominent symptoms. The combination therapy offers potential benefits in reducing side effects and accelerating the response to treatment. It is important to note that this study focused on short-term treatment, and further research is needed to evaluate the long-term efficacy and safety of this approach.

Dr.Camel's Conclusion

Imagine a camel navigating a treacherous desert landscape. Just as a guide can help navigate the dunes, cotherapy with clonazepam and fluoxetine provides additional support to those battling depression. This research offers a potential solution for individuals seeking a faster and more effective response to treatment.

Date :
  1. Date Completed 2001-01-26
  2. Date Revised 2022-12-07
Further Info :

Pubmed ID

11099743

DOI: Digital Object Identifier

10.1016/s0165-0327(99)00195-0

SNS
PICO Info
in preparation
Languages

English

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