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Treatment of myeloma. Comparison of melphalan, chlorambucil, and azathioprine.

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Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

A study of 73 patients with multiple myeloma compared the effectiveness of chlorambucil, melphalan, and azathioprine, all given with prednisone and fluoxymesterone. Melphalan was associated with higher response rates compared to the other two drugs. While survival curves were similar for patients with and without risk factors, blood urea nitrogen level was the only factor impacting survival.
Paper Details　
Original Abstract of the Article :
A randomized study compared the response of patients with multiple myeloma to chlorambucil, melphalan, and azathioprine. All patients also received a combination of prednisone and fluoxymesterone. Seventy-three of 86 patients entered on the study could have evaluations. The results indicate that mel...See full text at original site
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引用元：
https://doi.org/10.1001/archinte.135.1.157

データ提供：米国国立医学図書館（NLM）

Comparing Treatments for Multiple Myeloma

In the field of hematology, where the mysteries of blood and blood-forming organs are explored, researchers are constantly seeking more effective treatments for multiple myeloma, a cancer that affects plasma cells in the bone marrow. This study aimed to compare the effectiveness of three different chemotherapy regimens for this debilitating disease. The study involved 73 patients who were randomly assigned to receive one of three treatments: melphalan, chlorambucil, or azathioprine. All patients also received a combination of prednisone and fluoxymesterone. The researchers meticulously observed the patients' responses to each treatment, recording the effectiveness and side effects.

Melphalan Shows Superior Response Rates

This study revealed that melphalan produced a higher response rate than chlorambucil or azathioprine. This finding is significant because it suggests that melphalan could be a more effective treatment option for multiple myeloma. Think of it like choosing the right tool for the job; melphalan may be the more potent weapon in the fight against multiple myeloma.

Understanding the Role of Blood Urea Nitrogen Levels

This study also highlighted the importance of blood urea nitrogen (BUN) levels in predicting survival in patients with multiple myeloma. Patients with higher BUN levels, indicating compromised kidney function, had a lower survival rate. This finding underscores the need for careful monitoring of kidney function in patients undergoing chemotherapy for multiple myeloma. This is akin to observing the health of a delicate desert plant. Just as a plant's health depends on the quality of the surrounding soil, a patient's survival may be influenced by the health of their kidneys.

Dr. Camel's Conclusion

This research journey is akin to navigating a vast desert, seeking to understand the complex interplay of factors affecting survival in patients with multiple myeloma. The study's findings provide valuable insight into the effectiveness of different chemotherapy regimens and highlight the importance of kidney function in predicting survival. This research contributes to the ongoing pursuit of more effective treatments for multiple myeloma, offering hope for a future with improved outcomes for those battling this disease.
Date :
  1. Date Completed 1975-03-26
  2. Date Revised 2019-08-12
Further Info :

Pubmed ID

1111464

DOI: Digital Object Identifier

10.1001/archinte.135.1.157

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Article Analysis
・Effective treatment of multiple myeloma
SNS
PICO Info
in preparation
Languages

English

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