Paper Details

  1. Home
  2. Paper Details

Practical issues with COMT inhibitors in Parkinson's disease.

Author: WatersC

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This study discusses the practical considerations for using tolcapone and entacapone, two inhibitors of catechol-O-methyl transferase (COMT), as adjuncts to levodopa in Parkinson's disease. These agents are generally easy to administer and well tolerated, but patients need to be aware of possible side effects like dyskinesia, diarrhea, and liver dysfunction.
Paper Details　
Original Abstract of the Article :
Two inhibitors of catechol-O-methyl transferase (COMT), tolcapone and entacapone, have recently been introduced as adjuncts to levodopa in the treatment of Parkinson's disease patients. Both have been shown to provide PD patients with increased "on" time, decreased "off" time, and improved motor sco...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://pubmed.ncbi.nlm.nih.gov/11147511

データ提供：米国国立医学図書館（NLM）

Navigating the Sands of Parkinson's Disease Treatment with COMT Inhibitors

Parkinson's disease is a complex condition, like a vast and unforgiving desert landscape. Treatment options are constantly evolving, with new drugs and therapies emerging. This study focuses on COMT inhibitors, specifically tolcapone and entacapone, which are used to enhance the effects of levodopa, a common medication for Parkinson's. Think of these inhibitors as guides helping you traverse the treacherous terrain.

COMT Inhibitors: A Double-Edged Sword

While COMT inhibitors have been shown to improve motor function and increase 'on' time for patients, they also have side effects. These side effects are a reminder that even the best guides can sometimes lead you to unexpected paths. The study highlights the importance of careful monitoring and patient education to ensure that the benefits of COMT inhibitors outweigh the potential risks.

Navigating Side Effects with COMT Inhibitors

The study emphasizes that both the benefits and side effects of COMT inhibitors are related to increased dopaminergic activity. Therefore, it's important to adjust levodopa doses to manage any dyskinesia (involuntary movements) that may arise. The study also warns of explosive diarrhea as a possible side effect with tolcapone and the need for liver function monitoring. It's like a camel train encountering a sudden sandstorm, disrupting the journey.

Dr.Camel's Conclusion

This research is a reminder that even with promising new therapies, careful management and understanding are essential. It highlights the importance of balancing benefits and risks in Parkinson's disease treatment. Just as an experienced desert traveler understands the nuances of the terrain, physicians must carefully monitor patients on COMT inhibitors to ensure their safety and well-being.

Date :
  1. Date Completed 2001-01-25
  2. Date Revised 2018-11-30
Further Info :

Pubmed ID

11147511

DOI: Digital Object Identifier

11147511

Related Literature

Article Analysis
・Side Effects of tolcapone
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.