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Noradrenergic alpha-2 receptor agonists reverse working memory deficits induced by the anxiogenic drug, FG7142, in rats.

Author: ArnstenA F, BirnbaumS G, PodellD M

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

The anxiogenic drug FG7142 impaired working memory in mice. Pretreatment with the alpha-2A receptor agonist guanfacine completely blocked this impairment, while the less selective alpha-2 agonist clonidine only partially reversed it. This suggests that stimulating alpha-2A receptors may be a promising strategy for treating cognitive impairment associated with stress and anxiety.
Paper Details　
Original Abstract of the Article :
Performance on working memory tasks, a measure of prefrontal cortical function, is impaired by exposure to mild stress as well as the anxiogenic drug, FG7142. Previous studies have shown that like stress, FG7142 increases catecholamine release in the prefrontal cortex (PFC) and that high levels of d...See full text at original site
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引用元：
https://doi.org/10.1016/s0091-3057(00)00306-3

データ提供：米国国立医学図書館（NLM）

Alpha-2 Receptor Agonists: A Potential Oasis in the Desert of Cognitive Impairment

This research explores the intricate relationship between stress, anxiety, and cognitive function, focusing on the effects of the anxiogenic drug FG7142 on working memory in rats. The study investigates the potential of noradrenergic alpha-2 receptor agonists, such as clonidine and guanfacine, in reversing the working memory deficits induced by FG7142. The findings suggest that stimulation of the alpha-2A receptor subtype is particularly effective in mitigating these cognitive impairments. This research offers hope for developing novel therapeutic strategies for treating cognitive deficits associated with stress-related neuropsychiatric disorders.

Unlocking the Secrets of Cognitive Function in the Shifting Sands

This study delves into the complex interplay between stress, anxiety, and cognitive function, revealing the potential of alpha-2 receptor agonists in restoring cognitive function impaired by the anxiogenic drug FG7142. The research highlights the importance of understanding the neurochemical mechanisms underlying cognitive impairments in stress-related disorders, paving the way for the development of targeted therapies.

Navigating the Desert of Cognitive Impairment

The research into alpha-2 receptor agonists offers a promising path towards addressing cognitive impairments associated with stress-related neuropsychiatric disorders. This journey through the desert of cognitive function requires a comprehensive understanding of the neurochemical mechanisms at play, opening up possibilities for developing innovative and targeted therapies.

Dr. Camel's Conclusion

This research offers a glimmer of hope in the desert of cognitive impairment, revealing the potential of alpha-2 receptor agonists in reversing working memory deficits induced by stress and anxiety. By understanding the neurochemical mechanisms underlying these impairments, we can develop targeted therapies to restore cognitive function and improve the lives of individuals struggling with stress-related neuropsychiatric disorders.
Date :
  1. Date Completed 2001-04-19
  2. Date Revised 2019-07-12
Further Info :

Pubmed ID

11164065

DOI: Digital Object Identifier

10.1016/s0091-3057(00)00306-3

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in preparation
Languages

English

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