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The neuronal survival effects of rasagiline and deprenyl on fetal human and rat ventral mesencephalic neurones in culture.
Author: BradfordH F, GoggiJ, JauniauxE, RiazS S, SternG M, TheofilopoulosS
Original Abstract of the Article :
The neuronal survival properties of rasagiline (R(+)-N-propargyl-1-aminoindane mesylate or TVP-1012), a novel monoamine oxidase B inhibitor, have been investigated using neuronal cell cultures from fetal rat and human ventral mesencephalon. The ability of rasagiline to reduce the rate of neuronal ce...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元：
https://doi.org/10.1097/00001756-200012180-00007
データ提供：米国国立医学図書館（NLM）
Rasagiline: A Potential Protective Agent for Dopaminergic Neurons
The brain is a vast and intricate desert, filled with complex pathways and delicate connections. This study investigates the neuronal survival properties of rasagiline, a novel monoamine oxidase B inhibitor, using neuronal cell cultures from fetal human and rat ventral mesencephalon. The authors demonstrate that rasagiline is more effective than deprenyl, a widely used monoamine oxidase B inhibitor, in promoting neuronal survival, particularly for dopaminergic neurons. These findings suggest that rasagiline could have potential therapeutic applications in neurodegenerative diseases like Parkinson's disease, where dopaminergic neurons are specifically affected.
Rasagiline: A Potential Protective Agent for Dopaminergic Neurons
This study highlights the potential of rasagiline as a neuroprotective agent, particularly for dopaminergic neurons. The authors' findings demonstrate that rasagiline is more effective than deprenyl in promoting neuronal survival, suggesting that it could be a valuable tool for treating neurodegenerative diseases like Parkinson's disease.
Protecting the Desert Oasis of the Brain: Rasagiline's Potential
The brain, like a delicate desert oasis, requires careful preservation. This study suggests that rasagiline could play a crucial role in protecting the delicate balance of the brain, particularly in the face of neurodegenerative diseases. The authors' findings provide hope for developing new and effective therapies for conditions like Parkinson's disease, offering a potential path to preserving brain health and function.
Dr. Camel's Conclusion
This study offers promising insights into the neuroprotective potential of rasagiline. The authors' findings demonstrate that rasagiline is more effective than deprenyl in promoting neuronal survival, particularly for dopaminergic neurons. This research could lead to the development of new and effective treatments for neurodegenerative diseases like Parkinson's disease, offering a beacon of hope in the face of these debilitating conditions.
Date :
- Date Completed 2001-03-29
- Date Revised 2019-07-18
Further Info :
Related Literature
English
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