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In vivo and in vitro effects of octreotide, quinagolide and cabergoline in four hyperprolactinaemic acromegalics: correlation with somatostatin and dopamine D2 receptor scintigraphy.

Author: CappabiancaP, ColaoA, Del Basso de CaroM L, FaggianoA, FeroneD, LastoriaS, LombardiG, PivonelloR

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.

Overview

The study aims to evaluate the in vivo and in vitro sensitivity to SA and/or DA and correlate the response in terms of hormone suppression to the results of in vivo somatostatin and dopamine receptor scintigraphy and to the immunohistochemical findings.
Paper Details　
Original Abstract of the Article :
GH and PRL cosecretion frequently occurs in acromegaly and the sensitivity of both hormones to somatostatin analogs (SA) and dopamine agonists (DA) alone or in combination, is still debated. This study was designed to evaluate the in vivo and in vitro sensitivity to SA and/or DA and correlate the re...See full text at original site
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引用元：
https://doi.org/10.1046/j.1365-2265.2001.01080.x

データ提供：米国国立医学図書館（NLM）

Investigating the Effects of Octreotide, Quinagolide, and Cabergoline in Acromegaly: A Multifaceted Approach

Acromegaly, a condition characterized by excessive growth hormone (GH) production, presents a unique challenge in the world of endocrinology. This study explores the effects of various medications, including somatostatin analogs (SAs) and dopamine agonists (DAs), on GH and prolactin (PRL) secretion in patients with acromegaly. The researchers examined the in vivo and in vitro responses to these medications and correlated them with imaging results and immunohistochemical findings.

Optimizing Treatment Strategies for Acromegaly: A Multifaceted Approach

This study provides valuable insights into the complex interplay of GH and PRL secretion in acromegaly. The researchers investigated the effectiveness of various medications and their impact on hormone levels, providing a comprehensive understanding of treatment options. It's like a desert expedition – understanding the different elements of the landscape and their interactions is crucial for successful navigation.

The Importance of Personalized Treatment for Acromegaly

The study emphasizes the need for personalized treatment strategies for acromegaly. The effectiveness of different medications can vary depending on individual patient factors. It's like choosing the right tools for a desert trek – the success of our journey depends on our ability to adapt our approach to the unique challenges we encounter.

Dr.Camel's Conclusion

This study provides valuable information for clinicians treating patients with acromegaly. It highlights the importance of individualized treatment strategies and underscores the need for a multifaceted approach to effectively manage this complex condition. Like a skilled desert guide, we need to understand the nuances of the terrain to find the best path to optimal health.

Date :
  1. Date Completed 2002-01-03
  2. Date Revised 2019-08-13
Further Info :

Pubmed ID

11318782

DOI: Digital Object Identifier

10.1046/j.1365-2265.2001.01080.x

Related Literature

Article Analysis
・Effects of cabergoline
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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