Paper Details

  1. Home
  2. Paper Details

Inhibitory and bactericidal effects of telithromycin (HMR 3647, RU 56647) and five comparative antibiotics, used singly and in combination, against vancomycin-resistant and vancomycin-susceptible enterococci.

Author: BaltchA L, BoppL H, RitzW J, SmithR P

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Overview

Telithromycin demonstrated activity against enterococci, including vancomycin-resistant strains, but its bactericidal effects were limited. Further evaluation is needed to determine its potential role in treating enterococcal infections.
Paper Details　
Original Abstract of the Article :
The inhibitory and bactericidal effects of telithromycin (HMR 3647, RU 66647) were compared with those of gentamicin, ampicillin, erythromycin, azithromycin and vancomycin against 74 strains of enterococci (34 Enterococcus faecalis and 40 Enterococcus faecium) by agar dilution, broth dilution, time ...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1159/000048531

データ提供：米国国立医学図書館（NLM）

Telithromycin's Efficacy Against Enterococci, Including Vancomycin-Resistant Strains

This study investigates the inhibitory and bactericidal effects of telithromycin, a macrolide antibiotic, against various strains of enterococci, including those resistant to vancomycin, a crucial antibiotic for treating serious infections. The researchers compare telithromycin's activity to other antibiotics like gentamicin, ampicillin, erythromycin, and azithromycin.

Telithromycin's Potential for Treating Enterococcal Infections

The study found that telithromycin demonstrated varying levels of inhibitory activity against different strains of enterococci. While it showed bactericidal activity against some strains of E. faecium, its activity against E. faecalis was primarily inhibitory. The study suggests that telithromycin may be a potential therapeutic option for treating enterococcal infections, including those caused by vancomycin-resistant strains.

The Importance of Antibiotic Resistance

This research highlights the critical issue of antibiotic resistance, a growing threat to global health. The study underscores the importance of developing new antibiotics and understanding the mechanisms of resistance to ensure effective treatment options for bacterial infections. As a camel who has seen the ebb and flow of life in harsh environments, I recognize the importance of harnessing the power of medicine to combat disease.

Dr.Camel's Conclusion

This study contributes to our understanding of the efficacy of telithromycin against enterococci, a significant group of bacteria that can cause serious infections. It highlights the challenges of antibiotic resistance and the need for continued research to develop new and effective therapies. As we navigate the vast desert of infectious diseases, we must remain vigilant in our search for solutions to combat antibiotic resistance and protect human health.
Date :
  1. Date Completed 2001-07-19
  2. Date Revised 2017-11-01
Further Info :

Pubmed ID

11399861

DOI: Digital Object Identifier

10.1159/000048531

Related Literature

Article Analysis
・Effects of telithromycin
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.