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Gastrointestinal side effects of orlistat may be prevented by concomitant prescription of natural fibers (psyllium mucilloid).

Author: CavaliereH, FlorianoI, Medeiros-NetoG

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This placebo-controlled open study investigated whether the use of natural fibers (psyllium mucilloid) could prevent or ameliorate gastrointestinal (GI) side events induced by orlistat, a gastrointestinal lipase inhibitor, in obese patients.
Paper Details　
Original Abstract of the Article :
This placebo-controlled open study was designed to test the hypothesis that most of the gastrointestinal (GI) side events induced by treatment of obese patients with orlistat (a gastrointestinal lipase inhibitor) could be prevented or ameliorated by concomitant use of natural fibers (psyllium mucill...See full text at original site
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引用元：
https://doi.org/10.1038/sj.ijo.0801645

データ提供：米国国立医学図書館（NLM）

Preventing Gastrointestinal Side Effects of Orlistat with Natural Fibers

This research explores the potential for natural fibers, specifically psyllium mucilloid, to mitigate the gastrointestinal (GI) side effects associated with orlistat, a gastrointestinal lipase inhibitor commonly used for weight management. The study investigated the effects of concomitant use of psyllium mucilloid on GI side events in obese patients undergoing orlistat treatment.

Psyllium Mucilloid: A Potential Solution for GI Side Effects

The study suggests that concomitant prescription of psyllium mucilloid could effectively prevent or alleviate most of the GI side effects induced by orlistat treatment. This finding offers a promising approach for improving the tolerability of orlistat therapy, potentially increasing patient adherence and improving treatment outcomes.

The Importance of Addressing GI Side Effects in Weight Management

This study highlights the importance of addressing GI side effects in weight management strategies, particularly when using medications such as orlistat. It's like navigating a desert landscape with treacherous sandstorms, requiring strategies to mitigate the potential for discomfort and ensure a smoother journey towards achieving weight loss goals.

Dr.Camel's Conclusion

This study suggests a potential solution for mitigating the GI side effects associated with orlistat therapy, offering a more comfortable and tolerable weight management approach for patients. It's like discovering a hidden oasis in the desert of weight management research, providing a refreshing and effective way to minimize the challenges of GI side effects.

Date :
  1. Date Completed 2001-12-13
  2. Date Revised 2018-11-30
Further Info :

Pubmed ID

11443512

DOI: Digital Object Identifier

10.1038/sj.ijo.0801645

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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