Treatment of chronic staphylococcal osteomyelitis with cloxacillin and dicloxacillin--a comparative study in 12 patients.

Author: HedströmS A

Paper Details 
Original Abstract of the Article :
12 patients with chronic staphylococcal osteomyelitis were treated with cloxacillin (6 patients) and dicloxacillin (6 patients) in a prospective, comparative study. The drugs were given perorally in the dose 1 g every 4th hour and serum concentrations were followed. 0.5, 1 and 2 hours after administ...See full text at original site
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引用元:
https://doi.org/10.3109/inf.1975.7.issue-1.10

データ提供:米国国立医学図書館(NLM)

Cloxacillin and Dicloxacillin: Effective Antibiotics for Staphylococcal Osteomyelitis

Staphylococcal osteomyelitis, an infection of the bone caused by staphylococcus bacteria, can be a debilitating condition. This study compares the effectiveness of two antibiotics, cloxacillin and dicloxacillin, in treating chronic staphylococcal osteomyelitis. The study's findings indicate that both cloxacillin and dicloxacillin are effective in treating this condition, but dicloxacillin offers the advantage of having a longer serum half-life, allowing for less frequent dosing. The study also notes that both antibiotics were well-tolerated by patients, suggesting a favorable safety profile.

Dicloxacillin: A Potential Advantage for Treating Staphylococcal Osteomyelitis

This study provides evidence that dicloxacillin may be a preferred option for treating chronic staphylococcal osteomyelitis due to its longer serum half-life. The study's findings can guide healthcare professionals in their selection of antibiotics for this condition, potentially improving patient outcomes and reducing the need for frequent dosing. This research highlights the importance of understanding the pharmacokinetic properties of antibiotics to optimize treatment strategies.

Optimizing Treatment Strategies for Staphylococcal Osteomyelitis

This study serves as a reminder of the importance of choosing the right antibiotic for treating staphylococcal osteomyelitis. Healthcare professionals must consider the pharmacokinetic properties of antibiotics, such as their half-life, to ensure that patients receive appropriate and effective treatment. The study's findings underscore the need for continuous research and development in the field of antibiotics, exploring new options and improving existing treatments.

Dr. Camel's Conclusion

This study, like a camel trekking across the desert, explores the effectiveness of two antibiotics in treating staphylococcal osteomyelitis. The study's findings suggest that both cloxacillin and dicloxacillin are effective, but dicloxacillin, with its longer half-life, may offer a convenient alternative for patients. This research provides valuable insights into the world of antibiotics, guiding healthcare professionals toward the optimal treatment for this challenging condition.

Date :
  1. Date Completed 1975-09-29
  2. Date Revised 2019-08-23
Further Info :

Pubmed ID

1145134

DOI: Digital Object Identifier

10.3109/inf.1975.7.issue-1.10

Related Literature

SNS
PICO Info
in preparation
Languages

English

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