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Side-effects of oral misoprostol in the third stage of labour--a randomised placebo-controlled trial.

Author: DrakelyA, HofmeyrG J, NikodemV C, de JagerM

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Oral misoprostol 600 micrograms was associated with increased postpartum shivering (44% vs. 11%), pyrexia (38% vs. 6%), and hypertension compared to placebo.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Misoprostol, an inexpensive, stable, orally active prostaglandin analogue, has been suggested for use in the prevention of postpartum haemorrhage. Potential side-effects, however, need to be quantified. OBJECTIVE: To compare the rate of postpartum shivering and pyrexia following oral mi...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/11455810

データ提供：米国国立医学図書館（NLM）

Investigating the Side Effects of Oral Misoprostol in Labor

This research explores the potential side effects of oral misoprostol, a prostaglandin analogue, when used in the third stage of labor to prevent postpartum hemorrhage. The researchers conducted a double-blind, placebo-controlled trial to compare the incidence of shivering, pyrexia (fever), and other side effects in women receiving misoprostol versus placebo. Their findings provide valuable information for clinicians considering the use of misoprostol in labor, weighing its potential benefits against potential risks.

Misoprostol's Potential Side Effects: Shivering, Pyrexia, and Hypertension

The study found that oral misoprostol was associated with increased rates of shivering, pyrexia, and hypertension in the postpartum period. These findings highlight the need for careful monitoring of women receiving misoprostol, particularly for signs of these side effects. The researchers' findings underscore the importance of weighing the potential benefits of misoprostol against these potential risks before its use in labor.

Making Informed Decisions about Misoprostol Use in Labor

This study emphasizes the need for evidence-based decision-making when using misoprostol in labor. Clinicians should carefully consider the patient's individual risk factors and potential benefits before administering misoprostol, particularly in light of its potential for side effects. The researchers' findings suggest that further research is needed to optimize the use of misoprostol in labor, minimizing potential risks while maximizing its benefits.

Dr. Camel's Conclusion

This research reminds us that even in the vast and sometimes unpredictable desert of childbirth, there are hidden complexities. Understanding the potential side effects of medications like misoprostol is essential for making informed decisions about their use in labor, ensuring the safety and well-being of both mother and baby.

Date :
  1. Date Completed 2001-08-02
  2. Date Revised 2014-09-12
Further Info :

Pubmed ID

11455810

DOI: Digital Object Identifier

11455810

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SNS
PICO Info
in preparation
Languages

English

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