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In vitro and in vivo biologic effects of Ospemifene (FC-1271a) in breast cancer.

Author: DeGregorioM W, TarasT L, WurzG T

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

Ospemifene (FC-1271a) is a selective estrogen receptor modulator being developed to prevent osteoporosis. This study investigated the effects of FC-1271a on breast cancer models. In lab studies, FC-1271a and its metabolite inhibited the growth of MCF-7 breast cancer cells, which have estrogen receptors, and reduced the expression of pS2, a marker of estrogen activity. In living mice, FC-1271a slowed the growth of MCF-7 tumors compared to the control group. FC-1271a did not affect the growth of MDA-MB-231 cells, which lack estrogen receptors. These findings suggest that FC-1271a may have anti-estrogenic effects in breast cancer cells that express estrogen receptors.
Paper Details　
Original Abstract of the Article :
Ospemifene (FC-1271a) is a novel selective estrogen receptor modulator under development for osteoporosis prevention. In the present paper, we examine both the in vitro and in vivo effects of FC-1271a in breast cancer models. In vitro, the growth inhibitory effects of FC-1271a and its main metabolit...See full text at original site
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引用元：
https://doi.org/10.1016/s0960-0760(01)00066-8

データ提供：米国国立医学図書館（NLM）

In Vitro and In Vivo Biologic Effects of Ospemifene in Breast Cancer

This study investigates the anti-cancer effects of ospemifene (FC-1271a), a novel selective estrogen receptor modulator, in breast cancer models. The researchers examined both in vitro and in vivo effects of ospemifene on the growth of human breast cancer cells. The study found that ospemifene exhibited anti-estrogenic effects in vitro, inhibiting the growth of MCF-7 cells but not MDA-MB-231 cells. In vivo, ospemifene treatment inhibited MCF-7 tumor growth in athymic, ovariectomized mice.

Exploring the Anti-Cancer Potential of Ospemifene

This study reveals the potential of ospemifene as a therapeutic agent for estrogen receptor-positive breast cancer. The study demonstrates that ospemifene exhibits anti-estrogenic effects, effectively inhibiting the growth of MCF-7 cells both in vitro and in vivo. These findings suggest that ospemifene may be a promising candidate for the treatment of estrogen receptor-positive breast cancer.

Unveiling the Potential of Ospemifene: A New Frontier in Breast Cancer Treatment

This research illuminates the complex interplay between estrogen receptors and breast cancer development. Just as a camel adapts to its surroundings in the vast and unforgiving desert, ospemifene appears to modulate the effects of estrogen receptors in breast cancer cells. This research opens up new avenues for targeted breast cancer therapies, offering hope for patients and researchers alike.

Dr. Camel's Conclusion

This study sheds light on the potential of ospemifene as an anti-cancer agent, suggesting that it may be an effective treatment option for estrogen receptor-positive breast cancer. The journey to developing effective breast cancer treatments continues, and this research offers a valuable stepping stone towards a brighter future for those battling this disease.
Date :
  1. Date Completed 2001-08-23
  2. Date Revised 2019-09-01
Further Info :

Pubmed ID

11457665

DOI: Digital Object Identifier

10.1016/s0960-0760(01)00066-8

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Languages

English

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