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[Drug interactions with antiretroviral agents].

Author: FurlanV, TaburetA M

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

HIV-infected patients typically receive a combination of three or more antiretroviral drugs. These drugs are metabolized by an enzyme called CYP3A4. Some drugs, such as ritonavir, inhibit CYP3A4, while others, like nevirapine and efavirenz, induce it. This can lead to drug interactions. For instance, ritonavir is given with other antiretroviral drugs to increase their blood levels and effectiveness. Conversely, nevirapine and efavirenz may require increased doses of other drugs. Understanding these interactions is important to avoid adverse effects or reduced effectiveness. Coadministration with certain drugs, like rifampicin, astemizole, ergot derivatives, or cizapride, can be contraindicated due to potentially significant effects on drug levels. Clinical trials and reporting of side effects help identify unpredictable interactions and develop guidelines, as exemplified by therapeutic drug monitoring of methadone when coadministered with ritonavir or nelfinavir.
Paper Details　
Original Abstract of the Article :
Concomitant administration of three or more antiretroviral drugs is the standard treatment for HIV-infected patients. I.p. and NNRT are metabolized by cytochrome P450 and are inhibitors or inducers of CYP3A4. Therefore a number of drug-drug interactions are likely to occur. Ritonavir, a potent CYP3A...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/11475806

データ提供：米国国立医学図書館（NLM）

Drug Interactions with Antiretroviral Agents: A Complex Landscape

The treatment of HIV-infected patients often involves a combination of three or more antiretroviral drugs. This research focuses on the complex landscape of drug interactions that can occur when these medications are used together. The authors delve into the role of cytochrome P450, a key enzyme involved in drug metabolism, and its interactions with various antiretroviral agents. They highlight the potential for drug-drug interactions, including both beneficial and detrimental effects, and emphasize the importance of understanding these interactions to optimize treatment outcomes and minimize adverse effects.

Navigating the Drug Interaction Desert

The intricate world of drug interactions, especially those involving antiretroviral agents, is like a vast desert. This research, like a seasoned traveler's guide, helps navigate this complex terrain. Understanding the interplay of different medications and their impact on CYP3A4 activity is crucial for effective and safe HIV treatment.

Staying Hydrated in the Drug Interaction Desert

Navigating drug interactions in HIV treatment is essential for staying healthy. It's crucial to talk to your doctor about any medications you're taking, even over-the-counter options, to avoid potential complications. This research reminds us that awareness and careful monitoring are vital for successful HIV treatment.

Dr.Camel's Conclusion

The desert of drug interactions can be tricky to navigate, but this research provides some valuable signposts. By understanding the intricate interplay of antiretroviral medications, we can work towards optimal treatment and minimize the risk of unwanted side effects. It's a reminder that knowledge is a powerful tool for staying safe and healthy in the desert of medicine.

Date :
  1. Date Completed 2001-09-13
  2. Date Revised 2018-12-11
Further Info :

Pubmed ID

11475806

DOI: Digital Object Identifier

11475806

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