Effects of acute progesterone administration in healthy postmenopausal women and normally-cycling women.

Author: HaugerR, PurdyR, SchmittL, de WitH

Paper Details 
Original Abstract of the Article :
The goal of this study was to investigate the behavioral and subjective effects of single doses of progesterone (intramuscular) in post-menopausal women and in women with normal menstrual cycles. Although certain metabolites of progesterone (e.g., allopregnanolone) are known to bind to GABA(A) recep...See full text at original site
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引用元:
https://doi.org/10.1016/s0306-4530(01)00024-5

データ提供:米国国立医学図書館(NLM)

Progesterone: Exploring its Impact on Mood and Behavior

Progesterone, a female sex hormone, plays a crucial role in the menstrual cycle and pregnancy. This study investigated the potential effects of single doses of progesterone on mood and behavior in both postmenopausal women and women with normal menstrual cycles. While progesterone is known to have sedative-like effects in animals, the study found that in humans, even high doses of progesterone produced only mild sedative effects, contrary to expectations. This suggests that progesterone, at levels significantly higher than those typically experienced during the menstrual cycle, may have limited direct impact on mood.

Progesterone's Complex Role in Mood Regulation

The findings of this study provide valuable insights into the complex relationship between progesterone and mood. While progesterone has been linked to mood changes in some individuals, the study suggests that its direct impact on mood may be less significant than previously thought.

Navigating the Hormonal Landscape

Just as a camel navigates the desert with a remarkable sense of direction, understanding the intricate workings of hormones within our bodies is crucial for overall well-being. While progesterone may have a limited direct impact on mood, its overall role in the body is multifaceted, influencing various physiological processes.

Dr. Camel's Conclusion

The study sheds light on the limited impact of progesterone on mood and behavior in humans, even at high doses. This finding challenges previous assumptions and suggests that the complex relationship between progesterone and mood warrants further investigation.

Date :
  1. Date Completed 2001-10-04
  2. Date Revised 2019-09-15
Further Info :

Pubmed ID

11500251

DOI: Digital Object Identifier

10.1016/s0306-4530(01)00024-5

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SNS
PICO Info
in preparation
Languages

English

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