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The safety of higher than standard dose of doxylamine-pyridoxine (Diclectin) for nausea and vomiting of pregnancy.

Author: AtanackovicG, KorenG, MorettiM E, NaviozY

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the safety and efficacy of Diclectin, a medication used to treat nausea and vomiting during pregnancy. Diclectin was found to be safe and effective, even at higher than standard doses.
Paper Details　
Original Abstract of the Article :
A delayed-release combination of doxylamine-pyridoxine (D-P) (Diclectin) is the only approved antiemetic medication for use in pregnancy in Canada. The standard recommended dose is up to 4 tablets a day, regardless of body weight or severity of symptoms. The objective of this study was to determine ...See full text at original site
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引用元：
https://doi.org/10.1177/00912700122010735

データ提供：米国国立医学図書館（NLM）

Doxylamine-Pyridoxine (Diclectin) for Nausea and Vomiting of Pregnancy

This research investigates the safety and efficacy of doxylamine-pyridoxine (D-P) (Diclectin), a commonly prescribed antiemetic for nausea and vomiting of pregnancy (NVP). The study, based on a prospective observational design, analyzed the incidence of adverse maternal and fetal effects in women taking Diclectin at both the recommended and higher-than-recommended doses. The researchers meticulously assessed maternal side effects and pregnancy outcomes, including birth weight and gestational age. Their findings suggest that Diclectin can be safely used at doses higher than the standard recommendation, providing valuable insights for managing NVP in pregnant women.

Higher Doses of Diclectin: A Safe and Effective Approach

The study found no association between the dose of Diclectin and the incidence of maternal side effects, suggesting that higher doses can be safely administered. The researchers also observed no adverse effects on pregnancy outcomes, with birth weight and gestational age comparable to those in the general population. These findings provide reassurance for clinicians and pregnant women facing severe NVP.

Navigating the Rollercoaster of Pregnancy

This research provides valuable information for pregnant women and healthcare professionals navigating the challenges of NVP. The study's findings on the safety and efficacy of Diclectin at higher doses offer a valuable tool for managing this common pregnancy complication. It’s like finding a calming oasis in the desert of pregnancy-related nausea.

Dr. Camel's Conclusion

This study provides a reassuring beacon of hope for pregnant women struggling with nausea and vomiting. The findings suggest that Diclectin can be safely administered at higher doses, offering a potent tool for managing this common pregnancy complication. It's like finding a soothing remedy for the desert storms of pregnancy-related nausea.
Date :
  1. Date Completed 2001-12-13
  2. Date Revised 2019-08-26
Further Info :

Pubmed ID

11504271

DOI: Digital Object Identifier

10.1177/00912700122010735

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・Effects of doxylamine and pyridoxine
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PICO Info
in preparation
Languages

English

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