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The effects of two progrestogen-only pills containing either desogestrel (75 microgram/day) or levonorgestrel (30 microgram/day) on carbohydrate metabolism and adrenal and thyroid function.

Author: AgrenU, DiebenT, KiveläA, RuuskanenM

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Both desogestrel and levonorgestrel progestogen-only pills had minimal effects on carbohydrate metabolism. There was a trend for higher glucose and insulin values in the levonorgestrel group, but these changes were not considered clinically relevant. Both treatments were well tolerated.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: To compare the effects of two progestogen-only pills, containing either desogestrel or levonorgestrel, on carbohydrate metabolism, and adrenal and thyroid function. METHODS: In a double-blind, randomized, multicenter study in Finland, 84 healthy female volunteers received either desogest...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/11518451

データ提供：米国国立医学図書館（NLM）

Progestogen-Only Pills: A Comparative Study of Desogestrel and Levonorgestrel

This study examines the effects of two progestogen-only pills, desogestrel and levonorgestrel, on carbohydrate metabolism and adrenal and thyroid function. The researchers employed a double-blind, randomized, multicenter study to investigate the potential metabolic effects of these commonly used contraceptives. The results indicate that both desogestrel and levonorgestrel have minimal impact on carbohydrate metabolism, adrenal function, and thyroid function, suggesting that they are safe and well-tolerated options for women seeking hormonal contraception.

Minimal Impact on Metabolic Health

The study found no clinically relevant changes in carbohydrate metabolism, as evidenced by similar HbA1C values in both groups. Both desogestrel and levonorgestrel had minimal effects on adrenal and thyroid function, indicating that they are unlikely to interfere with the normal functioning of these crucial endocrine systems. The study provides reassurance regarding the metabolic safety of these progestogen-only pills.

Choosing the Right Contraceptive: Understanding the Options

This study highlights the importance of informed decision-making when choosing a contraceptive method. It provides valuable insights into the safety and metabolic impact of two commonly used progestogen-only pills, desogestrel and levonorgestrel. The research suggests that both options are well-tolerated and have minimal effects on important metabolic functions. By understanding the potential effects of these contraceptive options, women can make informed choices regarding their contraceptive needs.

Dr.Camel's Conclusion

This study provides valuable data for women seeking a reliable and well-tolerated progestogen-only pill. It demonstrates that both desogestrel and levonorgestrel have minimal impact on carbohydrate metabolism, adrenal function, and thyroid function, offering peace of mind to women seeking hormonal contraception. Just as a camel can traverse long distances in the desert with minimal impact on its body, these progestogen-only pills provide effective contraception with minimal metabolic interference. This research empowers women to make informed choices regarding their contraceptive needs, ensuring their health and well-being.

Date :
  1. Date Completed 2001-12-21
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

11518451

DOI: Digital Object Identifier

11518451

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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