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Comparative anti-staphylococcal effects of gemifloxacin and trovafloxacin in an in vitro dynamic model in terms of AUC/MIC and dose relationships.

Author: CornagliaG, FirsovA A, LubenkoI Y, PortnoyY A, VostrovS N, ZinnerS H

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Gemifloxacin and trovafloxacin had greater antimicrobial effects at AUC/MICs > 100 h, with trovafloxacin having a greater effect at 250 h.
Paper Details　
Original Abstract of the Article :
To compare the antimicrobial effects of gemifloxacin and trovafloxacin on Staphylococcus aureus, their pharmacodynamics were studied in an in vitro dynamic model. A series of pharmacokinetic profiles of gemifloxacin and trovafloxacin with half-lives of 7.4 and 9.2 h, respectively, were simulated in ...See full text at original site
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引用元：
https://doi.org/10.1016/s0732-8893(01)00264-4

データ提供：米国国立医学図書館（NLM）

Gemifloxacin and Trovafloxacin: A Comparative Analysis of Anti-Staphylococcal Effects

Staphylococcus aureus is a common bacterium that can cause a range of infections. This study compares the antimicrobial effects of two fluoroquinolones, gemifloxacin and trovafloxacin, against S. aureus, focusing on their pharmacokinetic and pharmacodynamic properties.

The researchers used an in vitro dynamic model to simulate the pharmacokinetic profiles of these drugs. They found that both gemifloxacin and trovafloxacin exhibited linear, species- and strain-independent relationships between the intensity of antimicrobial effect and the AUC/MIC ratio. However, at higher AUC/MIC ratios, trovafloxacin demonstrated a greater antimicrobial effect than gemifloxacin.

A Race Across the Desert of Antimicrobial Activity

This study is like a camel caravan racing across the desert, comparing the effectiveness of different antimicrobial agents against a common foe.

A Comparative Analysis of Anti-Staphylococcal Agents

This research is like a desert oasis offering a variety of remedies for combating a common infection – it provides a detailed comparison of the antimicrobial properties of gemifloxacin and trovafloxacin.

Dr. Camel's Conclusion

This study is like a camel caravan exploring two different routes through the desert – it provides a detailed comparison of the antimicrobial effectiveness of gemifloxacin and trovafloxacin, revealing the nuances of their respective strengths and weaknesses.

Date :
  1. Date Completed 2001-12-13
  2. Date Revised 2019-09-06
Further Info :

Pubmed ID

11576789

DOI: Digital Object Identifier

10.1016/s0732-8893(01)00264-4

Related Literature

Article Analysis
・Effects of gemifloxacin
SNS
PICO Info
in preparation
Languages

English

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