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Preoperative antiviral treatment and postoperative prophylaxis in HBV-DNA positive patients undergoing liver transplantation.

Author: BechsteinW O, BergT, MüllerA R, NaumannU, NeuhausP, NeuhausR, RayesN, SeehoferD, SteinmüllerT, TulliusS G

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This article discusses hepatitis B virus (HBV) recurrence following liver transplantation. Despite passive immunoprophylaxis, a significant number of patients develop HBV recurrence. Pretransplant antiviral therapy and postoperative combination therapy with antiviral agents and passive immunoprophylaxis may reduce the incidence of HBV recurrence.
Paper Details　
Original Abstract of the Article :
Despite passive immunoprophylaxis a significant number of patients, especially if hepatitis B virus (HBV) DNA is positive prior to transplantation, develop HBV recurrence. This number might be reduced by lowering viral replication pretransplant with antiviral agents and by postoperative combination ...See full text at original site
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引用元：
https://doi.org/10.1097/00007890-200110270-00008

データ提供：米国国立医学図書館（NLM）

Preemptive Antiviral Treatment for HBV-Positive Liver Transplant Recipients

Liver transplantation is a complex procedure, like navigating a vast desert with many obstacles. For patients with hepatitis B virus (HBV) DNA, the risk of HBV recurrence after transplantation is a significant concern. This research investigates the use of antiviral agents before and after transplantation to minimize this risk. The study suggests that combining antiviral treatment before transplantation with ongoing antiviral therapy and passive immunoprophylaxis after transplantation could be effective in preventing HBV recurrence.

Reducing the Risk of HBV Recurrence after Liver Transplantation

This study emphasizes the importance of preventative measures in managing HBV-positive patients undergoing liver transplantation. The results suggest that a combined approach of pre-transplant antiviral treatment and post-transplant antiviral therapy with passive immunoprophylaxis can potentially reduce the incidence of HBV recurrence. This research highlights the crucial need for tailored treatment strategies based on individual patient factors, including viral load and immune status.

Keeping Your Liver Healthy

Liver transplantation is a life-saving procedure for many patients. However, the risk of HBV recurrence can complicate recovery. This study underscores the importance of comprehensive management, including antiviral therapy and passive immunoprophylaxis, to ensure long-term success following liver transplantation.

Dr. Camel's Conclusion

This research provides valuable insights into managing HBV-positive patients undergoing liver transplantation. The study underscores the need for a multifaceted approach to reduce HBV recurrence. By combining pre-transplant antiviral therapy with post-transplant antiviral therapy and passive immunoprophylaxis, healthcare professionals can optimize patient outcomes and enhance their chances of a successful recovery.
Date :
  1. Date Completed 2001-12-04
  2. Date Revised 2019-07-13
Further Info :

Pubmed ID

11685107

DOI: Digital Object Identifier

10.1097/00007890-200110270-00008

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