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Gastrointestinal prokinetic drugs have different affinity for the human cardiac human ether-à-gogo K(+) channel.

Author: BaróI, BouyssouT, EscandeD, PotetF

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study compared the effects of four different 5-HT4 receptor agonists on cloned HERG channels and found that cisapride was the most potent blocker of HERG, while mosapride had no significant effects. This suggests that 5-HT4 agonists like mosapride could be safer alternatives to cisapride.
Paper Details　
Original Abstract of the Article :
Agonists of the serotonin 5-hydroxytryptamine 4 (5-HT4) receptor are widely used to activate motility in the gastrointestinal tract. Among these, cisapride was recently withdrawn from the U.S. market because of its proarrhythmic effects. Cisapride is a potent blocker of human ether-à-gogo (HERG) K(+...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/11714889

データ提供：米国国立医学図書館（NLM）

Gastrointestinal Prokinetic Drugs: A Careful Look at Cardiac Effects

Gastrointestinal prokinetic drugs are like skilled guides, helping to navigate the intricate pathways of the digestive system. However, some of these drugs have been known to cause unexpected side effects, particularly affecting the heart. This study investigates the effects of different gastrointestinal prokinetic drugs on the human ether-à-gogo (HERG) K+ channel, a key player in regulating heart rhythm.

Navigating the Desert of Cardiac Safety

The study highlights the importance of considering the potential cardiac effects of gastrointestinal prokinetic drugs. It's like being aware of the presence of hidden quicksand in the desert and taking precautions to avoid it. The researchers found that some prokinetic drugs, like cisapride, can block HERG channels, potentially disrupting heart rhythm. However, they identified other drugs, like mosapride, that did not show this effect, providing a safer alternative.

Ensuring a Safe Journey Through the Digestive System

This study emphasizes the need for careful consideration when prescribing gastrointestinal prokinetic drugs, particularly those that can affect cardiac function. It's like choosing a trusted guide who understands the dangers of the desert and can lead the way safely. By understanding the potential risks and benefits of different drugs, clinicians can select the most appropriate treatment for each patient, ensuring a smooth and safe journey through the digestive system.

Dr.Camel's Conclusion

This study underscores the importance of considering the potential cardiac effects of gastrointestinal prokinetic drugs, emphasizing the need for careful selection and monitoring. Just like a camel guide must be aware of the desert's hidden dangers, clinicians must have a comprehensive understanding of the potential risks and benefits of these medications to ensure the safety and well-being of their patients.
Date :
  1. Date Completed 2001-12-20
  2. Date Revised 2022-04-09
Further Info :

Pubmed ID

11714889

DOI: Digital Object Identifier

11714889

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Languages

English

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