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Suppression of hypothalamic-pituitary-adrenal axis activity with inhaled flunisolide and fluticasone propionate in adult asthma patients.

Author: CasaleT B, NelsonH S, NewmanK B, RaffH, StrickerW E

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Fluticasone caused significantly more suppression of HPA axis than flunisolide.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Suppression of the hypothalamic-pituitary-adrenal (HPA) axis, a potential systemic effect of inhaled corticosteroid therapy, can be quantified by monitoring serum, urinary, and salivary cortisol levels. OBJECTIVES: 1) Compare the effects on HPA axis of the inhaled corticosteroids flunis...See full text at original site
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引用元：
https://doi.org/10.1016/S1081-1206(10)62918-3

データ提供：米国国立医学図書館（NLM）

Inhaled Corticosteroids: Balancing Asthma Control and HPA Axis Suppression

Inhaled corticosteroids are commonly used to manage asthma but can potentially suppress the hypothalamic-pituitary-adrenal (HPA) axis, affecting cortisol levels. This study compared the effects of inhaled flunisolide and fluticasone propionate on HPA axis suppression in adult asthma patients. The researchers aimed to determine the relative potency of these corticosteroids and their impact on cortisol levels.

Fluticasone Propionate: A Potent Inhaled Corticosteroid with Significant HPA Axis Suppression

The study found that fluticasone propionate caused significantly more HPA axis suppression compared to flunisolide. The results suggest that fluticasone propionate may be more potent in controlling asthma but also carries a higher risk of HPA axis suppression. The study highlights the importance of carefully selecting inhaled corticosteroids based on individual patient needs and monitoring for potential side effects.

Balancing Asthma Control and Potential Side Effects: Choosing the Right Inhaled Corticosteroid

This research underscores the importance of balancing asthma control with potential side effects when choosing inhaled corticosteroids. While both flunisolide and fluticasone propionate effectively manage asthma, fluticasone propionate has a higher potency and may lead to greater HPA axis suppression. It emphasizes the need for close monitoring and individualized treatment plans to optimize asthma control while minimizing potential side effects.

Dr. Camel's Conclusion

This study provides valuable insights into the effects of inhaled corticosteroids on the HPA axis. Fluticasone propionate demonstrates greater potency in controlling asthma but also carries a higher risk of HPA axis suppression. Choosing the right inhaled corticosteroid involves balancing the benefits of asthma control with the potential for side effects. Remember, close monitoring and individualized treatment plans are essential for optimizing asthma management while minimizing potential risks.

Date :
  1. Date Completed 2001-12-14
  2. Date Revised 2021-09-01
Further Info :

Pubmed ID

11730179

DOI: Digital Object Identifier

10.1016/S1081-1206(10)62918-3

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Languages

English

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