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Does cognitive function improve with quetiapine in comparison to haloperidol?

Author: CsernanskyJohn, HoffAnne L, MahurinRoderick, MillerAlexander L, NewcomerJohn, PultzJoseph, VelliganDawn I

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study compared the effects of quetiapine and haloperidol on cognitive function in patients with schizophrenia. Results showed that patients receiving quetiapine 600 mg/day improved significantly on overall cognitive function, executive function, attention, and verbal memory compared to those receiving haloperidol.
Paper Details　
Original Abstract of the Article :
Recent evidence suggests that schizophrenia patients taking atypical antipsychotic medications may perform better on some tests of cognitive function than those treated with older antipsychotics. The current study compared the effects of quetiapine and haloperidol on measures of executive function, ...See full text at original site
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引用元：
https://doi.org/10.1016/s0920-9964(01)00268-7

データ提供：米国国立医学図書館（NLM）

Quetiapine vs. Haloperidol: A Cognitive Showdown

The field of [schizophrenia research] is constantly searching for better ways to manage the cognitive impairments associated with this complex disorder. This study compared the effects of quetiapine, an atypical antipsychotic, to haloperidol, a traditional antipsychotic, on measures of executive function, memory, and attention. The researchers conducted a randomized, double-blind, multi-site clinical efficacy study involving [58 stable outpatients with schizophrenia]. The patients underwent a battery of cognitive tests before and after 24 weeks of treatment with either quetiapine (600mg or 300mg per day) or haloperidol (12mg per day).

Quetiapine Emerges as a Cognitive Champion

The results revealed that patients receiving quetiapine 600mg per day showed greater improvement in overall cognitive function compared to those receiving haloperidol. Specifically, they demonstrated significant improvements in executive function, attention, and verbal memory.

Navigating the Cognitive Desert: Finding the Right Treatment

For individuals with schizophrenia, cognitive function plays a crucial role in their ability to function in everyday life. This research suggests that quetiapine, at a higher dose, may offer a potential advantage in improving cognitive performance, enhancing overall quality of life. However, it’s important to note that this study focused on specific cognitive domains, and further research is needed to fully understand the long-term effects of different antipsychotics on cognitive function.

Dr.Camel's Conclusion

Navigating the challenges of schizophrenia is like traversing a vast, shifting desert. Finding the right treatment is crucial for maintaining cognitive function and overall well-being. This study suggests that quetiapine, like a well-placed oasis, might provide much-needed relief for those struggling with cognitive impairments. However, remember, each individual’s journey is unique, and finding the right path requires careful consultation with a medical professional.

Date :
  1. Date Completed 2002-03-15
  2. Date Revised 2022-03-30
Further Info :

Pubmed ID

11738537

DOI: Digital Object Identifier

10.1016/s0920-9964(01)00268-7

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English

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