Comparison of long lasting therapeutic effects between succimer and penicillamine on hepatolenticular degeneration.

Author: LiFei, RenMing-Shan, WuJun-Xia, XueBen-Chun, YangRen-Min, ZhangZhi

Paper Details 
Original Abstract of the Article :
AIM:To compare the long-term effect of succimer (Suc) with that of penicillamine (Pen) in treating hepatolenticular degeneration (HLD).METHODS:One hundred and twenty patients with HLD were divided into 2 groups. Group A (n =60) received Suc 750mg,po.bid.Group B (n =60) received Pen 250mg, po. qid. T...See full text at original site
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引用元:
https://doi.org/10.3748/wjg.v4.i6.530

データ提供:米国国立医学図書館(NLM)

Succimer vs. Penicillamine: A Showdown in the Desert of Hepatolenticular Degeneration

Hepatolenticular degeneration, also known as Wilson's disease, is a rare genetic disorder that disrupts the body's ability to process copper. This study compares the long-term efficacy and safety of two medications, succimer (Suc) and penicillamine (Pen), in treating this complex condition. Like two rival explorers vying for dominance in a vast desert, researchers meticulously analyzed the clinical outcomes of these medications, seeking the most effective route to combat Wilson's disease.

Succimer Emerges Victorious: A Triumph in the Desert

The study found that succimer was significantly more effective than penicillamine in treating hepatolenticular degeneration. Succimer achieved higher rates of overall effectiveness and also demonstrated a favorable safety profile with fewer side effects. Succimer also proved beneficial for patients who had previously failed to respond to penicillamine treatment. Think of succimer as a resourceful explorer who navigates the challenges of Wilson's disease with greater success, while penicillamine struggles to overcome the harsh terrain.

Succimer: A Promising Weapon in the Arsenal Against Wilson's Disease

This study provides compelling evidence that succimer is a more effective and safer treatment option for hepatolenticular degeneration than penicillamine. The findings suggest that succimer should be considered the first-line therapy for long-term maintenance treatment of this condition. However, it is important to note that this study was conducted in a specific patient population, and further research is needed to confirm these findings in other groups.

Dr. Camel's Conclusion

This study is like a pivotal battle in the desert of Wilson's disease research. Succimer emerges as a formidable warrior, demonstrating superior efficacy and safety compared to penicillamine. While further research is needed to solidify its position as the gold standard treatment, this study offers a promising path towards effective and safe management of this complex condition.

Date :
  1. Date Completed n.d.
  2. Date Revised 2019-11-20
Further Info :

Pubmed ID

11819363

DOI: Digital Object Identifier

10.3748/wjg.v4.i6.530

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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